Effects of electrical stimulation on edema formation in different strains of rats

Physical Therapy
R M ThorntonD R Fish

Abstract

Although electrical stimulation (ES) is commonly used to curb edema formation, efficacy has been demonstrated in only one species of frog and one strain of rat. The purpose of this study was to determine whether different strains of rats respond differently to ES. Feet of Sprague-Dawley, Zucker-Lean, and Brown Norway rats were injured in a uniform manner. One foot served as a control, and the other foot received four 30-minute exposures to cathodal high-voltage pulsed current at amplitudes 10% less than those required to induce visible muscle activity. Each treatment period was followed by a 30-minute rest period. Limb volumes were measured before and after trauma and after each treatment and rest period. Changes from pretrauma volumes were analyzed by repeated-measures analysis of variance. Edema formation was curbed in Zucker-Lean and Brown Norway rats but not in Sprague-Dawley rats. The finding that two of the three strains of rats responded to ES suggests that some strains of rats may be suitable models for the study of edema. That frogs and rats respond to high-voltage pulsed current suggests that humans might respond similarly.

Citations

Jan 14, 2011·Plastic and Reconstructive Surgery·William J EnnisPatricio Meneses
Feb 6, 2007·Clinics in Dermatology·William J EnnisPatricio Meneses
Jan 4, 2012·Journal of Hand Therapy : Official Journal of the American Society of Hand Therapists·June P Villeco

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.