PMID: 20622480Jul 14, 2010Paper

Effects of electroacupuncture at Zusanli and Baihui on brain-derived neurotrophic factor and cyclic AMP response element-binding protein in the hippocampal dentate gyrus

The Journal of Veterinary Medical Science
In Koo HwangYeo Sung Yoon

Abstract

Previously, we observed that electroacupuncture (EA) at ST36 (Zusanli) and GV20 (Baihui) enhanced cell proliferation and neuroblast differentiation in the rat dentate gyrus. In this study, we investigated the possible mechanisms of EA in this effect. For this, we applied EA at ST36 and GV20 of Wistar rats (13-week-old) once a day for 3 weeks. Application of EA at these acupoints significantly increased the number of phosphorylated cyclic AMP response element-binding protein (pCREB)-immunoreactive cells in the dentate gyrus. In addition, EA significantly increased the levels of brain-derived neurotrophic factor (BDNF) and pCREB protein in the dentate gyrus. The administration of K252a, an inhibitor of BDNF receptor, significantly reduced cell proliferation in the subgranular zone of dentate gyrus. These results suggest that EA significantly increased neuroblast plasticity via pCREB and BDNF activation in the dentate gyrus.

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Citations

Jan 23, 2014·BMC Complementary and Alternative Medicine·Xuying LiQiang Wang
Feb 26, 2014·International Journal of Molecular Sciences·Dong LinChuanhai Cao
Aug 22, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Shuwei FengFanrong Liang
Jun 6, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Jian YangXin Ma
Oct 11, 2011·Journal of Acupuncture and Meridian Studies·Min-Ho NamSeung-hoon Choi
Feb 26, 2016·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Yang ZhangJiang-Peng Cao
Aug 6, 2016·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Min Deng, Xu-Feng Wang
Sep 27, 2014·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Li-Ya LiYue Zhao
Jul 8, 2020·International Journal of Molecular Sciences·Tzu-Hsuan Wei, Ching-Liang Hsieh
Nov 28, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Chun-Ping HuangChing-Liang Hsieh
Oct 19, 2019·Medical Acupuncture·Martin Torrents
Aug 6, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Hsiang-Chun LaiChing-Liang Hsieh
Oct 2, 2019·Frontiers in Aging Neuroscience·Jongjoo SunJ Mikhail Kellawan
Oct 27, 2020·Medical Acupuncture·Imtiaz Amrinusantara SurapatyIrawan Mangunatmadja

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