Effects of electronic cigarette liquid solvents propylene glycol and vegetable glycerin on user nicotine delivery, heart rate, subjective effects, and puff topography

Drug and Alcohol Dependence
Tory R SpindleT Eissenberg

Abstract

Electronic cigarettes (ECIGs) are a class of tobacco products that produce different effects (e.g., nicotine delivery), depending on the device, liquid, and behavioral factors. However, the influence of the two primary ECIG liquid solvents, propylene glycol (PG) and vegetable glycerin (VG), on ECIG acute effects is unknown. Thirty ECIG-experienced, ≥12-h nicotine- abstinent participants completed four conditions consisting of two ECIG-use bouts (10 puffs, 30 s interpuff-interval) differing only by liquid PG:VG ratio (2PG:98VG, 20PG:80VG, 55PG:45VG, 100PG). Device power (7.3 W) and liquid nicotine concentration (18 mg/ml) remained constant. Nicotine delivery, subjective effects, heart rate (HR), and puff topography were assessed. In the 100PG condition, participants took shorter and smaller puffs but obtained significantly more nicotine relative to the two VG-based conditions. Total nicotine exposure (i.e., area under the curve) was also significantly higher during use of the two PG-based liquids. However, participants reported that the 100 PG liquid was significantly less "pleasant" and "satisfying" relative to the other liquids (all ps < .05). Increases in HR and decreases in abstinence symptoms (e.g., "craving") did not diffe...Continue Reading

References

Aug 11, 1979·British Medical Journal·H AshtonJ W Thompson
May 1, 1978·Journal of Pharmaceutical Sciences·D P Vaughan, M Dennis
Nov 1, 1991·British Journal of Addiction·S T Tiffany, D J Drobes
Mar 1, 1986·Archives of General Psychiatry·J R Hughes, D Hatsukami
Jun 1, 1994·Psychopharmacology·W B PickworthJ E Henningfield
Feb 8, 2003·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Alison B BrelandThomas Eissenberg
Nov 1, 2003·Pharmacology, Biochemistry, and Behavior·Jed E RoseAl Salley
Jun 8, 2006·Experimental and Clinical Psychopharmacology·Sarah E EvansThomas Eissenberg
Nov 30, 2006·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Alison B BrelandThomas Eissenberg
Jul 22, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Andrea R VansickelThomas E Eissenberg
Dec 4, 2010·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Caroline O CobbThomas Eissenberg
Apr 21, 2011·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Melissa D BlankThomas Eissenberg
Oct 9, 2012·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Yaping ZhangDa-Ren Chen
Feb 19, 2013·American Journal of Preventive Medicine·Sarah E AdkisonGeoffrey T Fong
May 17, 2014·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Leon KosmiderMaciej Lukasz Goniewicz
Sep 3, 2014·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Alan Shihadeh, Thomas Eissenberg
Jan 17, 2016·Annals of the New York Academy of Sciences·Alison BrelandThomas Eissenberg
May 12, 2016·Journal of Analytical Toxicology·Michelle R PeaceAlphonse Poklis
May 29, 2016·Psychopharmacology·Lynne E DawkinsOlivia Corcoran
Jun 10, 2016·MMWR. Morbidity and Mortality Weekly Report·Girija SyamlalJacek M Mazurek
Sep 11, 2016·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Hyoshin KimPamela I Clark
Jan 11, 2017·Psychopharmacology·Peter HajekHayden McRobbie
Jul 15, 2017·Aerosol Science and Technology : the Journal of the American Association for Aerosol Research·Soha TalihAlan Shihadeh
Nov 22, 2017·Chemical Research in Toxicology·Zachary T BitzerJohn P Richie
Jan 1, 2017·Aerosol Science and Technology : the Journal of the American Association for Aerosol Research·Mohammad BaassiriAlan Shihadeh

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Citations

Mar 9, 2019·Annual Review of Analytical Chemistry·Robert M Strongin
Jul 26, 2019·PloS One·Jessica M YingstAndrea L Hobkirk
Apr 18, 2019·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Elise E DeVitoMehmet Sofuoglu
Aug 14, 2019·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Tracy T SmithMatthew J Carpenter
May 5, 2020·Environmental Health Perspectives·Silke Schmidt
Aug 8, 2020·BMC Cardiovascular Disorders·Hesham BasmaBrian D Lowes
Jun 28, 2020·Neuropharmacology·Asti JacksonSuchitra Krishnan-Sarin
Mar 23, 2021·Function·Robert TarranLoren E Wold
Feb 12, 2020·Tobacco Control·Sarah MaloneyAlison Breland
Nov 5, 2021·Tobacco Control·Marzena HilerElena V Mishina
Nov 11, 2021·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Jude A FrieJibran Y Khokhar

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