Effects of embryonic ethanol exposure at low doses on neuronal development, voluntary ethanol consumption and related behaviors in larval and adult zebrafish: Role of hypothalamic orexigenic peptides

Behavioural Brain Research
M E SterlingSarah F Leibowitz

Abstract

Embryonic exposure to ethanol is known to affect neurochemical systems in rodents and increase alcohol drinking and related behaviors in humans and rodents. With zebrafish emerging as a powerful tool for uncovering neural mechanisms of numerous diseases and exhibiting similarities to rodents, the present report building on our rat studies examined in zebrafish the effects of embryonic ethanol exposure on hypothalamic neurogenesis, expression of orexigenic neuropeptides, and voluntary ethanol consumption and locomotor behaviors in larval and adult zebrafish, and also effects of central neuropeptide injections on these behaviors affected by ethanol. At 24h post-fertilization, zebrafish embryos were exposed for 2h to ethanol, at low concentrations of 0.25% and 0.5%, in the tank water. Embryonic ethanol compared to control dose-dependently increased hypothalamic neurogenesis and the proliferation and expression of the orexigenic peptides, galanin (GAL) and orexin (OX), in the anterior hypothalamus. These changes in hypothalamic peptide neurons were accompanied by an increase in voluntary consumption of 10% ethanol-gelatin and in novelty-induced locomotor and exploratory behavior in adult zebrafish and locomotor activity in larvae. ...Continue Reading

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Citations

Jan 17, 2017·Zebrafish·Steven TranRobert Gerlai
Jun 18, 2019·Alcoholism, Clinical and Experimental Research·Adam D CollierSarah F Leibowitz
Sep 5, 2020·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Jaquelinne Pinheiro-da-SilvaAna Carolina Luchiari
Jul 16, 2020·Chemico-biological Interactions·Paulo FernandesLuís Félix
Oct 24, 2021·Developmental Neurobiology·José Henrique Cararo, Eduardo Pacheco Rico

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