Abstract
Pulmonary emphysema impairs lung and respiratory muscle function leading to restricted physical capacity and accelerated morbidity and mortality consequent to respiratory muscle failure. In the absence of direct evidence, an O2 supply-demand imbalance within the diaphragm and other respiratory muscles in emphysema has been considered the most likely explanation for this failure. To test this hypothesis, we utilized phosphorescence quenching techniques to measure mean microvascular PO2 (PO2m) within the medial costal diaphragm of control (C, n = 10) and emphysematous (E, elastase instilled, n = 7) hamsters. PO2m and mean arterial pressure (MAP) were measured in the spontaneously breathing anesthetized hamster at inspired O2 percentages of 10, 21, and 100, and across a range of mean MAPs from 40 to 115 mm Hg. At each inspired O2, diaphragm PO2m was significantly (p < 0.05) lower in E animals (10%: C, 19 +/- 3; E, 9 +/- 2; 21%: C, 32 +/- 2; E, 21 +/- 2; 100%: C, 60 +/- 8; E, 36 +/- 9 mm Hg). At 21% inspired O2, the PO2m decrease was correlated with reduced MAP in both C (r = 0.968) and E (r = 0.976) animals. We conclude that diaphragmatic PO2m (and therefore microvascular O2 content) is decreased in emphysematous hamsters reflecti...Continue Reading
References
Apr 1, 1979·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J J O'BrienG L Snider
Jul 1, 1979·Archives of Biochemistry and Biophysics·D F WilsonI A Silver
Oct 1, 1977·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·G L Snider, C B Sherter
Oct 1, 1992·Journal of Applied Physiology·P J Ohtake, D B Jennings
Jul 1, 1992·Journal of Applied Physiology·D C Poole, O Mathieu-Costello
Mar 1, 1992·Journal of Applied Physiology·M I LewisG C Sieck
Sep 1, 1991·Respiration Physiology·J P Mortola
Jan 1, 1988·Respiration; International Review of Thoracic Diseases·J Tamaoki
Jan 1, 1988·Journal of Applied Physiology·S N HussainS Magder
Sep 23, 1988·Science·W L RumseyD F Wilson
Nov 1, 1986·The American Review of Respiratory Disease
Oct 1, 1984·The Journal of Clinical Investigation·G A Farkas, C Roussos
Apr 1, 1984·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J O Holloszy, E F Coyle
Jun 1, 1983·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·G A Farkas, C Roussos
Sep 1, 1983·The Journal of Clinical Investigation·N ViiresC Roussos
Sep 1, 1994·Journal of Applied Physiology·T MatsuokaJ P Mortola
Feb 1, 1996·American Journal of Respiratory and Critical Care Medicine·S C GandeviaA De Troyer
Apr 5, 1996·Analytical Biochemistry·L W LoD F Wilson
Dec 1, 1995·The Journal of Clinical Investigation·H SuzukiG W Schmid-Schönbein
Dec 1, 1995·Journal of Applied Physiology·D C PooleD F Wilson
Feb 1, 1997·Journal of Applied Physiology·D C Poole, O Mathieu-Costello
Apr 1, 1997·American Journal of Respiratory and Critical Care Medicine·A De TroyerS C Gandevia
Jun 1, 1997·Medicine and Science in Sports and Exercise·D C PooleM B Reid
Apr 16, 1998·Journal of Applied Physiology·W L Sexton, D C Poole
Jan 1, 1997·Advances in Experimental Medicine and Biology·L W LoD F Wilson
Apr 6, 2000·Journal of Applied Physiology·M Fournier, M I Lewis
Nov 1, 1958·The American Journal of Physiology·K SCHMIDT-NEILSEN, J L LARIMER
Mar 1, 1959·The Journal of Clinical Investigation·R M CHERNIACK
Citations
Mar 22, 2012·European Journal of Applied Physiology·Andreas N KavazisDonna M Gordon
Aug 26, 1998·Life Sciences·N PedrónM E Fonseca
Aug 1, 2012·Critical Care Medicine·Robert T DavisBradley J Behnke
Apr 11, 2009·Journal of Applied Physiology·Thomas L Clanton, Sanford Levine
Oct 9, 2012·Journal of Applied Physiology·Bradley J BehnkeMichael D Delp
Mar 5, 2002·American Journal of Respiratory and Critical Care Medicine·Martin J Tobin
Jan 22, 2009·The Tohoku Journal of Experimental Medicine·Tomoko KutsuzawaMunetaka Haida
Sep 17, 2004·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Lale KostakogluStanley J Goldsmith
Dec 7, 2013·Der Anaesthesist·C S BruellsR Rossaint
Dec 21, 2006·COPD·Anne K SwisherRachel Yeater
May 26, 2009·Current Problems in Diagnostic Radiology·Xia Wang, Spencer Koch
Jun 5, 2007·Experimental Physiology·Richard A Howlett, Michael C Hogan
Oct 3, 2012·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Roland N Pittman
Dec 31, 2017·The Journal of Physiology·Daniel M HiraiDavid C Poole
Aug 19, 2018·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Daniel M HiraiDavid C Poole
Jun 5, 2019·Journal of Applied Physiology·Andrew G HornBradley J Behnke
Apr 5, 2005·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Roland N Pittman
Sep 2, 2021·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Andrew G HornBradley J Behnke