Effects of enalapril and eprosartan on the renal vascular nitric oxide system in human essential hypertension

Kidney International
Christian DellesR E Schmieder

Abstract

Experimental data in humans on the contribution of angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor blockers to the nitric oxide system of the renal vasculature are inconsistent. Enalapril and eprosartan, alone and in combination, were used to determine their short-term effects on the renal nitric oxide system and renal hemodynamics of human subjects with essential hypertension. Twenty male, white patients (27 +/- 1 years) with mild essential hypertension (143 +/- 11/95 +/- 6 mm Hg) were included in a double-blind, randomized, placebo-controlled, fourfold cross-over study with placebo, enalapril (20 mg/day), eprosartan (600 mg/day), or combination of both drugs (10 and 300 mg/day, respectively) each over a one week period followed by a two-week washout phase. After each study phase the glomerular filtration rate (GFR) and renal plasma flow (RPF) were determined. Basal nitric oxide synthesis of the renal vasculature was assessed by the decrease in RPF after inhibition of nitric oxide synthase with NG-monomethyl-L-arginine (L-NMMA; 4.25 mg/kg). After one week of therapy, the combination therapy decreased casual blood pressure by 5 +/- 2/3 +/- 1 mm Hg versus placebo (P < 0.01). Neither enalapril alone (-...Continue Reading

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Citations

Sep 2, 2011·European Journal of Clinical Pharmacology·Feng-Ying XuXue-Yin Shi
Dec 25, 2012·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Christian OttRoland E Schmieder
Mar 29, 2002·Kidney International·Marina Noris, Giuseppe Remuzzi
Mar 9, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Christian DellesRoland E Schmieder
Jul 10, 2002·Current Opinion in Nephrology and Hypertension·Maarten W Taal, Barry M Brenner
Aug 10, 2004·Current Opinion in Nephrology and Hypertension·Christian Delles, Roland E Schmieder
Jul 26, 2006·Blood Pressure·Sebastian OehmerRoland E Schmieder
Jan 10, 2008·Current Medical Research and Opinion·C Venkata S Ram
Jul 15, 2015·Journal of the American Society of Nephrology : JASN·Anna-Lena ForstUrsula Storch
May 12, 2004·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Radko KomersTerezie Pelikanova
Sep 14, 2002·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Domenic A Sica
Mar 8, 2006·Hypertension·Bernhard M W SchmidtRoland E Schmieder
Apr 10, 2004·Stroke; a Journal of Cerebral Circulation·Christian DellesRoland E Schmieder
Dec 20, 2007·Journal of Hypertension·Markus P SchlaichRoland E Schmieder
Jan 12, 2007·The Journal of Clinical Hypertension·Domenic A Sica
Mar 3, 2007·Pharmacological Reviews·Noboru TodaTomio Okamura
Feb 10, 2017·American Journal of Physiology. Renal Physiology·Alberto MontanariDavid Z I Cherney

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