PMID: 11746258Dec 18, 2001Paper

Effects of endocrine disrupting chemicals on the microtubule network in Chinese hamster V79 cells in culture and in Sertoli cells in rats

Teratogenesis, Carcinogenesis, and Mutagenesis
M NakagomiH Ono

Abstract

The effects of ten endocrine disrupting chemicals, i.e., bisphenol A (BPA), p-nonylphenol (NP), p-octylphenol (OP), p-pentylphenol (PP), butyl benzyl phthalate (BBP), dicyclohexyl phthalate (DCHP), di-n-butyl phthalate (DBP), tetrabutyltin (TBT), tri-n-butyltin chloride (TBC), and di-n-butyltin dichloride (DBD), as well as 17 beta-estradiol (E(2)) as a positive control on the microtubule network in Chinese hamster V79 cells in culture were examined by the indirect immunofluorescence method using anti-beta-tubulin antibody. In the whole-animal system, the effects of BPA, NP, OP, BBP, DBD, and E(2) as well as vinblastine sulfate (VB) as a positive control on microtubules in the cytoplasm of Sertoli cells in rats were examined by electron microscopy. In Chinese hamster V79 cells, TBC and DBD showed higher microtubule-disruptive activity than E(2), while other chemicals had less activity than E(2). The ranking for efficiency on microtubule disruption was (TBC falling dots DBD) > (E(2) = TBT) > (BPA = alkylphenols, NP and OP) > (phthalate esters, BBP, DHP, and DBP). In rats as a whole-animal system, no disrupting effects on the microtubule network in the cytoplasm of Sertoli cells were observed under any environmental chemicals test...Continue Reading

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Citations

Oct 24, 2002·Teratogenesis, Carcinogenesis, and Mutagenesis·Timothy J SchraderW Cherry
Jan 30, 2008·ACS Chemical Biology·Olivia GeorgeCharles B Shuster
Jan 24, 2009·Biology of Reproduction·Ailene MuhlhauserPatricia A Hunt
Nov 13, 2012·Mutation Research·Edna Ribeiro-VarandasMargarida Delgado
Apr 7, 2009·Toxicology and Applied Pharmacology·Nikki GillumNarine Sarvazyan
Dec 22, 2007·Mutation Research·Ursula Eichenlaub-RitterJim Parry
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Jul 7, 2009·Reproductive Toxicology·Maria BondessonJan-Ake Gustafsson
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May 25, 2016·EMBO Reports·Alessandro PagliusoFabrizia Stavru

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