PMID: 3519339Apr 1, 1986

Effects of endogenous and exogenous secretin on plasma pancreatic polypeptide concentrations in dogs

Diabetologia
F KoizumiJ Kameyama

Abstract

The effects of exogenous and endogenous secretin with or without intravenous glucose infusion upon islet hormone secretion were studied in four conscious mongrel dogs fitted with a duodenal fistula. Intravenous infusion of secretin for 1 h at doses of 0.5 and 4 U/kg raised plasma secretin concentrations to physiological and pharmacological levels respectively, without affecting plasma insulin and pancreatic polypeptide concentrations. In contrast, bolus injections of secretin at high concentrations produced significant increases of plasma insulin at 0.5 U/kg and 4 U/kg and of pancreatic polypeptide at 4 U/kg. Plasma glucagon did not change during intravenous infusion of low dose secretin (0.5 U X kg-1 X h-1), but decreased during infusion of 4 U X kg-1 X h-1 or bolus injection of secretin (0.5 U/kg). Intravenous infusion of glucose together with secretin (0.5 U/kg and 4 U/kg) did not affect plasma insulin, glucagon, or pancreatic polypeptide levels significantly compared with the changes caused by glucose infusion alone. Intraduodenal instillation of HCl, which produced plasma secretin concentrations similar to those evoked by intravenous infusion of secretin (4 U X kg-1 X h-1), led to a rise in plasma pancreatic polypeptide. I...Continue Reading

References

Dec 19, 2012·General and Comparative Endocrinology·Revathi Sekar, Billy K C Chow
Jun 16, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Eugenio Bertelli, Moïse Bendayan

Citations

Jul 1, 1976·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·O B de MuckadellC Kühl
Jan 22, 1977·Lancet·T E AdrianR C Russell
Oct 1, 1978·Gut·T E AdrianS R Bloom
Jan 1, 1977·Scandinavian Journal of Gastroenterology·O B Schaffalitzky de MuckadellK B Lauritsen
Jan 1, 1978·Scandinavian Journal of Gastroenterology·L KayassehJ Girard
Dec 1, 1976·Gut·T E AdrianA J Barnes
Jul 1, 1977·The Journal of Clinical Endocrinology and Metabolism·R L Lerner
Apr 1, 1967·The Journal of Clinical Investigation·R H UngerA M Eisentraut
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Aug 1, 1972·The Journal of Clinical Investigation·R L Lerner, D Porte
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Sep 1, 1973·Annals of Surgery·D D ReederJ C Thompson
Jul 1, 1973·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·R J DudlR H Williams
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Jun 10, 1967·British Medical Journal·D R BoynsH Keen
Aug 1, 1982·Scandinavian Journal of Gastroenterology·R Jorde, P G Burhol
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Related Concepts

PPY gene
Glucagon (rDNA)
Duodenal Fistula
Mixed breed dog
Intravenous Injections
Secretin Measurement
Duodenum
Glucose, (beta-D)-Isomer
Hormone Secretion
Glucagon

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