Effects of endogenous and synthetic prostanoids, the thromboxane A2 receptor agonist U-46619 and arachidonic acid on [3H]-noradrenaline release and vascular tone in rat isolated kidney

British Journal of Pharmacology
L C Rump, P Schollmeyer

Abstract

1. Rat kidneys were perfused with Krebs-Henseleit solution and the perfusion pressure was monitored. After incubation with [3H]-noradrenaline the renal nerves were stimulated. The stimulation-induced (S-I) outflow of radioactivity was taken as an index of noradrenaline release. The effect of prostaglandins on perfusion pressure, pressor responses to renal nerve stimulation (RNS) and S-I outflow of radioactivity was assessed. 2. Prostaglandin E2 (PGE2, 0.06 and 0.6 microM), PGF2 alpha (0.6 microM), PGI2 (0.6 and 3 microM) and iloprost (0.6 microM) increased perfusion pressure and enhanced pressor responses to RNS. These facilitatory effects of the prostaglandins were not a result of an enhanced transmitter release. In contrast, PGE2 dose-dependently inhibited, whereas the other prostaglandins failed to modulate S-I outflow of radioactivity. PGE2 (0.6 microM) also enhanced pressor responses to exogenous noradrenaline. 3. Arachidonic acid (1 microM) increased perfusion pressure and enhanced pressor responses to RNS. These effects were abolished in the presence of indomethacin (10 microM) suggesting that local production of prostaglandins from exogenous arachidonic acid was responsible for this facilitation. However, arachidonic ac...Continue Reading

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Citations

Nov 12, 1991·European Journal of Pharmacology·Y J Li, S P Duckles
Mar 17, 1992·European Journal of Pharmacology·L MantelliF Ledda
Nov 1, 1992·The American Review of Respiratory Disease·K RackéI Wessler
Oct 11, 2011·Prostaglandins & Other Lipid Mediators·Omar MoussaPerry V Halushka
Sep 1, 2015·Prostaglandins & Other Lipid Mediators·Na HuangJinshan Cao
Jan 1, 1990·Annals of the New York Academy of Sciences·K U Malik, E Sehic
Sep 1, 1989·Klinische Wochenschrift·L C Rump, P Schollmeyer

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