Effects of endothelial NOS antagonism within the periaqueductal gray on cardiovascular responses and neurotransmission during mechanical, heat, and cold nociception

Brain Research
Kevin A ChaitoffA Ally

Abstract

Nitric oxide (NO) is synthesized from L-arginine using NO synthase (NOS) enzyme that exists as 3 isoforms: endothelial (eNOS), neuronal (nNOS), and inducible (iNOS). We examined the role of eNOS within the dorsolateral periaqueductal gray mater (dlPAG) on cardiovascular responses along with glutamate and GABA concentrations during mechanical-, heat-, and cold-induced nociception in anesthetized rats. Mechanical stimulus was applied by a 10-second hindpaw pinch that increased mean arterial pressure (MAP) and heart rate (HR). Bilateral microdialysis of a selective eNOS antagonist, L-N(5)-(1-iminoethyl)ornithine (L-NIO; 10 microM), into the dlPAG had no effect on MAP or HR during a mechanical stimulation. Heat stimulus was generated by immersing a hindpaw metatarsus in a water-bath at 52 degrees C for 10 s which increased glutamate, GABA, MAP and HR. Administration of L-NIO into the dlPAG augmented cardiovascular responses and glutamate increase, but attenuated GABA changes during the heat stimulus. In contrast, application of a cold stimulus by immersing the hindpaw at 10 degrees C for 10 s resulted in decreases in MAP, HR, and glutamate. However, there was an increase in GABA concentration. Following microdialysis of L-NIO into ...Continue Reading

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Citations

Nov 10, 2011·Rheumatology International·Juvenia Bezerra Fontenele, Francisco Helder Cavalcante Felix
Jun 29, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Kevin A ChaitoffAhmmed Ally
Oct 2, 2014·The International Journal of Neuroscience·Giovane S GaldinoAndrea C Perez
Apr 26, 2012·Experimental Neurology·Philippe BonninChristiane Charriaut-Marlangue
Aug 31, 2011·Nitric Oxide : Biology and Chemistry·Thiago R L RomeroIgor D G Duarte
Oct 26, 2012·Cells, Tissues, Organs·Elisa BorsaniLuigi F Rodella
Jun 27, 2020·Nitric Oxide : Biology and Chemistry·Ahmmed AllySurya M Nauli

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