Effects of endothelin-1 on [Ca2+]i-shortening trajectory and Ca2+ sensitivity in rabbit single ventricular cardiomyocytes loaded with indo-1/AM: comparison with the effects of phenylephrine and angiotensin II

Journal of Cardiac Failure
S Fujita, M Endoh

Abstract

In most mammalian species, activation of myocardial endothelin as well as alpha1-adrenergic and angiotensin receptors leads to an increase in contractile function and myocardial cell hypertrophy, in association with acceleration of PI hydrolysis and with resultant production of IP3 and diacylglycerol. Therefore, these receptors may share a common intracellular signal transduction process in cardiac regulation. Although the pathophysiological relevance of endothelin- and angiotensin-mediated signal transduction has been postulated to play a key role in the progress of congestive heart failure, the details of the regulation are still controversial. We carried out experiments to further study the regulation induced by activation of these receptors. In spite of a wide range of species-dependent variation among mammals in the induction of the cardiotonic effect via these receptors, there is an excellent correlation between the extent of acceleration of PI hydrolysis and the positive inotropic effect (associated with a negative lusitropic effect) of the respective receptor agonists under most experimental conditions in rabbit ventricular myocardium. In isolated rabbit ventricular cardiomyocytes loaded with indo-1/AM, activation of th...Continue Reading

References

Jul 1, 1978·European Journal of Pharmacology·M KobayashiS Chiba
Sep 7, 1976·Biochemical and Biophysical Research Communications·Y IkeharaK Kato
Aug 6, 1992·European Journal of Pharmacology·M EndohI Norota
Dec 1, 1992·Pflügers Archiv : European journal of physiology·H ItoE Carmeliet
Jul 1, 1991·The American Journal of Physiology·D C KemM B Vallotton
Apr 1, 1991·Journal of Molecular and Cellular Cardiology·S A ChenC I Lin
Feb 28, 1989·Biochemical and Biophysical Research Communications·C S MoravecM Bond
Sep 1, 1981·Journal of Molecular and Cellular Cardiology·R S Kass, M L Blair
Jun 1, 1993·Naunyn-Schmiedeberg's Archives of Pharmacology·J ZhangP A van Zwieten

❮ Previous
Next ❯

Citations

Aug 23, 2012·PloS One·Tepmanas Bupha-IntrPaul M L Janssen
Jun 27, 2006·Journal of Pharmacological Sciences·Masao Endoh
Jan 22, 2005·European Journal of Pharmacology·Li Chu, Masao Endoh
Mar 20, 1998·Circulation Research·M C Camilión de HurtadoH E Cingolani
Jul 17, 2001·American Journal of Physiology. Heart and Circulatory Physiology·M A TalukderM Endoh
Jul 26, 2011·The International Journal of Artificial Organs·Lorenzo FassinaGiovanni Magenes
Sep 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Geir Øystein AndersenTor Skomedal

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.