Effects of endothelin antagonist tezosentan on orthodontic tooth movement in rats

American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics
M DrevensekG Drevensek

Abstract

Endothelin is a cytokine peptide present in the periodontal ligament in physiological conditions. Its concentration in the periodontal ligament doubles after 3 hours of axial loading of a tooth. The role of endothelin in orthodontic tooth movement has not yet been explained. We tried to determine the effect of tezosentan, a specific dual endothelin receptor antagonist, on orthodontic tooth movement in rats. Twenty-one rats were divided into 3 groups (n = 7). In the tezosentan group, closed-coil springs were placed, and the animals were treated daily with tezosentan; in the coil-spring group, closed-coil springs were placed, and the animals were treated with an inert physiological solution. The appliance was placed between the maxillary left first molar and the incisor. The third group was the control group. On days 0, 7, 14, and 25, the distances between the maxillary molars and incisors were measured at the experimental and contralateral sides. Changes in measured distances at the experimental sides were significantly different between the tezosentan and the coil-spring groups on day 25 (P < .001), with the tezosentan group showing greater changes in the measured distances. There were no differences between the tezosentan and ...Continue Reading

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Citations

Oct 12, 2010·Photomedicine and Laser Surgery·Sabrina K C GamaAntonio Luiz B Pinheiro
Dec 15, 2010·Photomedicine and Laser Surgery·Mariana MarquezanMônica Tirre de Souza Araújo
Dec 15, 2010·Photomedicine and Laser Surgery·Fernando A L HabibAntônio L B Pinheiro
Feb 11, 2012·Photomedicine and Laser Surgery·Fernando A L HabibAntônio L B Pinheiro
Dec 17, 2008·European Journal of Orthodontics·M DrevensekG Drevensek
Apr 25, 2008·Journal of Dental Research·G E Wise, G J King
Nov 5, 2013·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Christian KirschneckPiero Roemer
Dec 27, 2011·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Ningning ZhaoYan Liu
Apr 5, 2011·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Alja MehMartina Drevenšek
Jul 24, 2013·Dental press journal of orthodontics·Mariana MarquezanMônica Tirre de Souza Araújo
Nov 19, 2019·Archives of Oral Biology·Lucas Garcia SantanaSaulo Gabriel Moreira Falci

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