PMID: 8596725Mar 1, 1996Paper

Effects of endotoxin infusion on mean systemic filling pressure and flow resistance to venous return

Pflügers Archiv : European journal of physiology
M HiesmayrA Versprille

Abstract

Mean systemic filling pressure (Psf) is an indicator of the filling state of the systemic circulation. Cardiac output (Q') is related linearly to the difference between Psf and central venous pressure (Pcv), according to: Q' = (Psf - Pcv)/Rsf, where Rsf is the flow resistance downstream from the sites where blood pressure is equal to Psf. In 16 anaesthetized pigs we evaluated Psf, Rsf and Q' during baseline conditions, continuous endotoxin infusion and after subsequent fluid loading. Psf and Rsf were determined from simultaneous measurements of Q' and Pcv at seven levels of lung inflation. The following results were obtained. Psf was 8.1 +/- 1.8 mm Hg (mean +/- SD) during baseline conditions, increased after endotoxin infusion to 9.9 +/- 3.2 mm Hg (P = 0.04) and remained the same after infusion of 18 ml kg-1 of Ringer s lactate. Rsf increased from 0.34 +/- 0.07 to 0.80 +/- 0.34 mm Hg ml-1 s by endotoxin and decreased after fluid infusion to 0.58 +/- 0.14. Q' changed inversely proportional to Rsf (P = 0.001). Rsf changes were highly correlated with the changes in total systemic flow resistance (Rs) (P < 0.001). Endotoxin caused haemoconcentration and a decrease in plasma volume. The stability of Psf during endotoxin infusion and...Continue Reading

References

Mar 1, 1976·The Journal of Trauma·P P BrownL J Greenfield
Oct 1, 1989·Journal of Applied Physiology·J R JansenA Versprille
Oct 1, 1987·Journal of Applied Physiology·J R JansenA Versprille
Oct 1, 1985·Pflügers Archiv : European journal of physiology·A Versprille, J R Jansen
Mar 1, 1974·Circulation Research·J A Drees, C F Rothe
Mar 1, 1969·The American Journal of Physiology·J W PratherA C Guyton
Oct 22, 1983·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·J E KusterE J Sanders
Mar 1, 1984·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·M R Pinsky
Sep 1, 1981·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J R JansenA Versprille
Feb 1, 1993·Journal of Applied Physiology·C F Rothe
Jun 1, 1957·The American Journal of Physiology·A C GUYTONT RICHARDSON
Mar 1, 1955·The American Journal of Physiology·A C GUYTONB N KAUFMANN

❮ Previous
Next ❯

Citations

Aug 11, 2011·Journal of Clinical Monitoring and Computing·Jacinta J MaasJos R C Jansen
Feb 20, 2010·Current Opinion in Critical Care·Jos R C JansenMichael R Pinsky
Dec 28, 2012·Critical Care Medicine·Duane J FunkAnand Kumar
Aug 29, 2012·Critical Care Medicine·Romain PersichiniXavier Monnet
Apr 19, 2015·Current Opinion in Critical Care·Hollmann D Aya, Maurizio Cecconi
May 1, 2021·European Journal of Anaesthesiology·Aarne FeldheiserMatthias Stopfkuchen-Evans

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.