Effects of endotoxin tolerance on liver function after hepatic ischemia/reperfusion injury in the rat

Critical Care Medicine
Fernández E DomínguezF U Schade

Abstract

It is known that endotoxin tolerance prevents lethality after ischemia/reperfusion injuries (e.g., myocardial infarction) in laboratory animals. We used a rat model of partial hepatic ischemia/reperfusion to investigate whether endotoxin tolerance prevents associated lethality and disorders of liver function. Prospective animal study. University research facility. Male Sprague-Dawley rats. Hepatic ischemia was initiated by atraumatic clipping across the portal venous and hepatic arterial blood supply to the left lateral lobe for 90 mins. The common bile duct was canalized, and in a second set of experiments the bile duct of the left lateral lobe was canalized selectively. Bile flow, bile acids, and transaminases were determined during ischemia and 300 mins of reperfusion in endotoxin-tolerant and -nontolerant rats. Endotoxin-nontolerant animals showed a 50% lethality after hepatic ischemia/reperfusion injuries. All endotoxin-tolerant rats survived and did not react with any change in bile flow, showing a constant flow. The amount of bile acids in the common bile duct was reduced during ischemia and regained the concentrations of sham-operated animals 60 mins after reperfusion. From 180 mins after reperfusion, the difference bet...Continue Reading

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Citations

Jul 15, 2005·Best Practice & Research. Clinical Anaesthesiology·Nina C Weber, Wolfgang Schlack
Feb 27, 2009·Critical Care Medicine·Annelies DraismaJohannes G van der Hoeven
Dec 2, 2006·Transplant Immunology·Kohei IshiyamaToshimasa Asahara
Aug 28, 2009·Innate Immunity·Annelies DraismaPeter Pickkers

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