PMID: 8600189Mar 1, 1996Paper

Effects of endurance exercise and hormone replacement therapy on serum lipids in older women

Journal of the American Geriatrics Society
E F BinderW M Kohrt

Abstract

To determine the effects of 11 months of exercise training and hormone replacement therapy (HRT), alone or in combination, on serum lipids and lipoproteins, in postmenopausal women. Controlled, prospective, 11-month clinical trial. Healthy postmenopausal women (n = 71, age range 60-72 yrs) were assigned to four groups in a 2 X 2 design (control, exercise, HRT, exercise + HRT). Large, midwestern urban community; subjects were recruited from the community-at-large. The exercise program was conducted at a university exercise facility. HRT consisted of conjugated estrogens at 0.625 mg/day and trimonthly medroxyprogesterone acetate 5 mg/day for 13 days. Exercise consisted of 2 months of low intensity exercise followed by 9 months of vigorous exercise for 45 min/day, 3 or more days/week, at 65-85% of maximal heart rate. Maximal aerobic power (VO2max), resting blood pressure, body composition, serum lipids and lipoproteins, and dietary intake at baseline and after 11 months. At the end of 11 months, subjects in the exercise group had decrease total cholesterol (TC; P < .01) and LDL-cholesterol (LDL-C; P < .05), but there was no change in HDL-cholesterol (HDL-C) or triglycerides. Women in the HRT group had decreased LDL-C (P < .001) an...Continue Reading

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