PMID: 9430011Jan 16, 1998Paper

Effects of enprostil on gastric endocrine secretion during chronic administration of lansoprazole

Journal of Gastroenterology
N OmuraY Fukuchi

Abstract

We investigated changes in the secretory kinetics of gastric endocrine cells related to the administration of lansoprazole, and the effects of enprostil on these altered kinetics. Male Wistar-derived 8-week-old rats were allotted to a control group, a lansoprazole administration group, an enprostil administration group, and a lansoprazole + enprostil administration group. Lansoprazole (30 mg/kg once a day for 4 weeks) and enprostil (10 micrograms/kg twice a day for 4 weeks) were administered into the gastric lumen with a gastric tube. At this time, blood was collected and immunohistological staining of gastric endocrine cells was conducted to investigate the secretory kinetics. Lansoprazole administration induced hypergastrinemia, increase of gastrin cells, and increase of enterochromaffin-like cells. Enprostil administration induced increase of somatostatin cells. The group administered lansoprazole + enprostil exhibited significant decreases in serum gastrin level, total gastrin cell count, and total enterochromaffin-like cell count, compared with the group administered lansoprazole alone. These findings suggest that enprostil may ameliorate the alteration in gastric endocrine secretion produced by the chronic administration ...Continue Reading

References

Jan 1, 1989·Scandinavian Journal of Gastroenterology. Supplement·W CreutzfeldtG Brunner
Apr 1, 1989·European Journal of Clinical Investigation·A UribeC Johansson
Jul 1, 1993·Scandinavian Journal of Gastroenterology·N OmuraT Aoki

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Citations

Aug 5, 2005·Biological & Pharmaceutical Bulletin·Susumu Okabe, Kikuko Amagase
Aug 21, 2002·Journal of Pediatric Gastroenterology and Nutrition·Michele Scaillon, Samy Cadranel

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