PMID: 2498074May 1, 1989Paper

Effects of enteral tube feeding on the absorption and pharmacokinetic profile of carbamazepine suspension

Epilepsia
J BassM D Thorn

Abstract

In a randomized, two-period crossover clinical study, eight normal male volunteers received two separate 500-mg doses of carbamazepine (CBZ) suspension 1 week apart. One dose was administered orally after an overnight fast, and the other was administered by nasogastric feeding tube during a continuous enteral feeding infusion. Serial serum CBZ concentrations were determined by high-performance liquid chromatography (HPLC) to assess the effects of the enteral feeding on CBZ absorption. Noncompartmental methods were used to estimate pharmacokinetic data. One volunteer experienced a mild hypersensitivity reaction after his first CBZ dose and was withdrawn from the study. The other subjects tolerated both doses very well, although most experienced mild drowsiness or lightheadedness. Serum CBZ concentrations were lower during enteral feeding administration, but the differences were statistically significant only at 8 h (p = 0.044). Changes in pharmacokinetic data were not significant, although the decrease in maximum serum concentration approached significance (p = 0.052). The relative bioavailability of CBZ suspension with enteral feeding administration was 90.1% of that during fasting. There was a strong correlation between CBZ do...Continue Reading

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Citations

Jul 24, 2007·Annals of Emergency Medicine·Thomas B PurcellRobert Chavez
Apr 23, 2013·Journal of Clinical Pharmacy and Therapeutics·L-L Zhu, Q Zhou
Feb 24, 2006·Epilepsy & Behavior : E&B·Andrea O Rossetti, Edward B Bromfield
Jun 14, 2016·International Journal of Pharmaceutics·Ching Kim TyeMichael J Hageman
Nov 25, 2005·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Barbara L MagnusonAndrew C Bernard
Aug 5, 2015·Therapeutic Advances in Psychopharmacology·Giovanni OrioloEduard Parellada
Dec 5, 2008·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Nancy Toedter Williams
Aug 12, 2009·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Paul D WohltJeffrey T Fish
Feb 1, 1990·DICP : the Annals of Pharmacotherapy·J G Strom, S W Miller
Aug 30, 2005·Antimicrobial Agents and Chemotherapy·Paul BeringerAnnie Wong-Beringer
Apr 13, 2019·Current Nutrition Reports·Joseph I Boullata
Dec 30, 2020·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Joseph I Boullata

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