Effects of Enterococcus faecium NCIMB 10415 as probiotic supplement on intestinal transport and barrier function of piglets

Archives of Animal Nutrition
Ulrike LodemannHolger Martens

Abstract

Many studies report positive effects of probiotic supplementation on the performance and health of piglets. The intention of this study was to describe the effects of Enterococcus faecium NCIMB 10415 on the transport and barrier functions of pig small intestine to improve our understanding of the underlying mechanisms of this probiotic. Ussing chamber studies were conducted with isolated jejunal epithelia of piglets at the age of 14, 28, 35 and 56 days. Jejunal tissues of the control group were compared with epithelia of piglets that had received a diet supplemented with the probiotic Enterococcus faecium NCIMB 10415. Transport properties (absorption and secretion) of the epithelia were examined by mucosal addition of glucose or L-glutamine or by serosal addition of PGE2. Electrophysiology of the epithelia was continuously recorded and the change in short circuit current (Isc) was determined. Paracellular permeability was measured by measuring the flux rates of mannitol. The increase of Isc caused by mucosal addition of glucose was, at all glucose concentrations, higher in the probiotic group compared with the control group. However, the difference (up to 100% of the control) was not significant. The increase of Isc after the m...Continue Reading

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Citations

Feb 10, 2011·The British Journal of Nutrition·Peter J A WijttenMartin W A Verstegen
Mar 27, 2012·Animal : an International Journal of Animal Bioscience·M KennyB Miller
Aug 30, 2013·Canadian Journal of Physiology and Pharmacology·Kevin W Lomasney, Niall P Hyland
Apr 13, 2010·International Journal of Food Microbiology·Francesca GaggìaBruno Biavati
Oct 20, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Pieter AnnaertPatrick Augustijns
Jul 22, 2014·Journal of Animal Physiology and Animal Nutrition·E M GefellerU Lodemann
Jan 17, 2017·Polish Journal of Veterinary Sciences·M M Abd El-TawabN D Giadinis
Aug 9, 2017·Bioscience of Microbiota, Food and Health·Jean Daniel Dubreuil
May 1, 2021·Animals : an Open Access Journal From MDPI·Gerald C ShursonPedro E Urriola
Jul 3, 2013·ACS Synthetic Biology·Katherine VolzingYiannis N Kaznessis

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