DOI: 10.1101/515262Jan 9, 2019Paper

Effects of enucleation on the direct reciprocal corticocortical connections between primary visual and somatosensory cortices of the mouse

BioRxiv : the Preprint Server for Biology
Ian O MasséD Boire

Abstract

Multisensory convergence is present in the cerebral cortex even at the initial stages of processing in the primary and low-level sensory cortices. Direct connections between primary sensory cortices are a particular feature of rodent cortical connectivity. Our previous studies have shown asymmetric projections between the primary visual and somatosensory cortices in mice. Binocular enucleation produces a relative reduction of the projections from the somatosensory cortex to the visual cortex in mice. The purpose of this study is to compare the direct reciprocal cross-modal connections between the primary visual (V1) and somatosensory (S1) cortices in intact and enucleated C57Bl/6 mice, and to determine quantitative differences in the proportion and laminar distribution of neurons and terminals in these projections. CTB labeled neurons were used to estimate the relative importance of projections between V1 and S1, and their laminar distribution used to classify them as feedback, feedforward or lateral projections. The size of axonal swellings was measured and frequency distribution determined for each cortical layer. Axon diameters were also sampled in these connections. Injections in V1 resulted in a reduced proportion of label...Continue Reading

Related Concepts

Axon
Cerebral Cortex
Enucleation Procedure
Laboratory mice
Neurons
Rodent
Somatosensory Cortex
Vision, Binocular
Visual Cortex
Spatial Projection

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.