Effects of Environmental Manipulations and Treatment with Bupropion and Risperidone on Choice between Methamphetamine and Food in Rhesus Monkeys

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Matthew L Banks, B E Blough

Abstract

Preclinical and human laboratory choice procedures have been invaluable in improving our knowledge of the neurobiological mechanisms of drug reinforcement and in the drug development process for candidate medications to treat drug addiction. However, little is known about the neuropharmacological mechanisms of methamphetamine vs food choice. The aims of this study were to develop a methamphetamine vs food choice procedure and determine treatment effects with two clinically relevant compounds: the monoamine uptake inhibitor bupropion and the dopamine antagonist risperidone. Rhesus monkeys (n=6) responded under a concurrent schedule of food delivery (1-g pellets, fixed-ratio (FR) 100 schedule) and intravenous methamphetamine injections (0-0.32 mg/kg/injection, FR10 schedule) during 7-day bupropion (0.32-1.8 mg/kg/h) and risperidone (0.001-0.0056 mg/kg/h) treatment periods. For comparison, effects of removing food pellets or methamphetamine injections and FR response requirement manipulations were also examined. Under saline treatment conditions, food was preferred over no methamphetamine or small unit methamphetamine doses (0.01-0.032 mg/kg/injection). Larger methamphetamine doses resulted in greater methamphetamine preference an...Continue Reading

References

Dec 1, 1977·Pharmacology, Biochemistry, and Behavior·R M WursterJ V Brady
Aug 1, 1981·Drug and Alcohol Dependence·W L Woolverton, R L Balster
Aug 21, 2001·Psychopharmacology·C L HartM W Fischman
Mar 15, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·S Stevens Negus
Dec 2, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Thomas F NewtonRoberta Kahn
Jan 5, 2007·The American Journal of Psychiatry·Jari TiihonenEsa Meririnne
Mar 1, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sunmee WeeGeorge F Koob
Jun 22, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ahmed M ElkashefDennis Weis
Feb 20, 2008·Psychopharmacology·Margaret Haney, Roger Spealman
Mar 11, 2008·Pharmacology, Biochemistry, and Behavior·Carmela M ReichelRick A Bevins
Apr 26, 2008·Drug and Alcohol Dependence·S D ComerS L Walsh
May 13, 2008·Drug and Alcohol Dependence·Steven ShoptawWalter Ling
May 23, 2008·Pharmacology, Biochemistry, and Behavior·Ansong Ping, Paul J Kruzich
Nov 18, 2008·Drug and Alcohol Dependence·Carmela M ReichelRick A Bevins
Dec 3, 2008·The Journal of Biological Chemistry·J Shawn GoodwinHabibeh Khoshbouei
Feb 10, 2010·Journal of Psychopharmacology·Amanda E HigleyEliot L Gardner
Feb 24, 2011·Experimental and Clinical Psychopharmacology·Charles W SchindlerSteven R Goldberg
Jun 1, 2009·Journal of Addiction Medicine·Charles W MeredithAndrew J Saxon
Oct 22, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·William W StoopsCraig R Rush
Apr 11, 2012·International Journal of Psychiatry in Clinical Practice·Ahmad Hatim SulaimanNg Chong Guan
Sep 13, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Matthew L BanksS Stevens Negus
Oct 11, 2012·Pharmacology, Biochemistry, and Behavior·J Adam BennettCraig R Rush
Jan 4, 2013·BMC Research Notes·Xin Wen, Michael L Paine
Aug 21, 2013·Journal of Clinical Psychopharmacology·Irene M LakoKatja Taxis
Sep 3, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·William W StoopsCraig R Rush
Dec 3, 2014·Pharmacology, Biochemistry, and Behavior·William W StoopsCraig R Rush

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Citations

May 27, 2015·Current Treatment Options in Psychiatry·Matthew L BanksS Stevens Negus
Dec 6, 2016·Trends in Pharmacological Sciences·Matthew L Banks, S Stevens Negus
Mar 1, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·E Andrew TownsendMatthew L Banks
May 3, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·E Andrew TownsendMatthew L Banks
Oct 8, 2020·Nature Reviews. Neuroscience·Marco VenniroYavin Shaham
Jan 15, 2020·Cold Spring Harbor Perspectives in Medicine·E Andrew TownsendMatthew L Banks
Dec 4, 2020·Drug and Alcohol Dependence·E Andrew TownsendMatthew L Banks

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