Effects of environmentally relevant concentrations of diclofenac in Mytilus trossulus

The Science of the Total Environment
Klaudia ŚwiackaMagda Caban

Abstract

The presence of pharmaceuticals in the marine environment is a growing problem of global importance. Although awareness of the significance of this issue is increasing, many questions related to the ecotoxicology of pharmaceuticals remain unclear. Diclofenac is one of the drugs most commonly detected in the marine environment and its potential toxicity has been previously highlighted, thus its impact on organisms deserves a special attention. Therefore, in this study, a thorough analysis of the effects of diclofenac on a condition and tissue level of a model representative of marine invertebrates - Mytilus trossulus - was performed. During the 25-day experiment, divided into exposure and depuration phases, bivalves were exposed to two environmentally relevant drug concentrations of 4 and 40 μg/L. The study showed that mussels absorb diclofenac in their tissues and the highest recorded concentration was 1.692 μg/g dw on day 8. Moreover, the content of diclofenac metabolites (4-OH and 5-OH diclofenac) was also examined, but they were not detected either in water or in tissues. Although exposure to low diclofenac concentrations did not significantly affect the condition index of organisms, changes in numerous histopathological par...Continue Reading

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Citations

Jun 18, 2021·The Science of the Total Environment·Ewa MulkiewiczMagda Caban
Nov 10, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Alexey A MorozovVictoria V Yurchenko
Dec 22, 2021·Environmental Toxicology and Chemistry·Nadezhda A BerezinaOlga A Malysheva

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