Effects of EPA and lipoic acid supplementation on circulating FGF21 and the fatty acid profile in overweight/obese women following a hypocaloric diet

Food & Function
Xavier EscotéM J Moreno-Aliaga

Abstract

FGF21 has emerged as a key metabolism and energy homeostasis regulator. Dietary supplementation with eicosapentaenoic acid (EPA) and/or α-lipoic acid (LIP) has shown beneficial effects on obesity. In this study, we evaluated EPA and/or LIP effects on plasma FGF21 and the fatty acid (FA) profile in overweight/obese women following hypocaloric diets. At the baseline, FGF21 levels were negatively related to the AST/ALT ratio and HMW adiponectin. The weight loss did not cause any significant changes in FGF21 levels, but after the intervention FGF21 increased in EPA-supplemented groups compared to non-EPA-supplemented groups. EPA supplementation decreased the plasma n-6-PUFA content and increased n-3-PUFAs, mainly EPA and DPA, but not DHA. In the LIP-alone supplemented group a decrease in the total SFA and n-6-PUFA content was observed after the supplementation. Furthermore, EPA affected the desaturase activity, lowering Δ4D and raising Δ5/6D. These effects were not observed in the LIP-supplemented groups. Besides, the changes in FGF21 levels were associated with the changes in EPA, n-3-PUFAs, Δ5/6D, and n-6/n-3 PUFA ratio. Altogether, our study suggests that n-3-PUFAs influence FGF21 levels in obesity, although the specific mechani...Continue Reading

References

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Citations

Mar 21, 2019·Current Opinion in Lipidology·Dicky StruikJohan W Jonker
Jan 24, 2020·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Artur BjelicaJelena Cvejić
Dec 20, 2019·Journal of Physiology and Biochemistry·Marta Fernández-GalileaMaria J Moreno-Aliaga
Aug 14, 2019·Biomolecules·Bahare SalehiJavad Sharifi-Rad
Aug 8, 2021·International Journal of Molecular Sciences·Luc Rochette, Steliana Ghibu

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Methods Mentioned

BETA
X-ray
enzyme-linked immunosorbent assay
ELISA

Clinical Trials Mentioned

NCT01138774

Software Mentioned

StataCorp
Stata
TotalChrom
Lunar , Prodigy

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