Effects of ephedrine on human nasal ciliary beat frequency

ORL; Journal for Oto-rhino-laryngology and Its Related Specialties
Luo ZhangZhongyan Liu

Abstract

The purpose of this study was to investigate the effects of ephedrine, an alpha,beta-adrenoceptor agonist, on the regulation of human nasal ciliary beat frequency (CBF). Changes in (cultured) human nasal CBF in response to 0.25, 0.5, 1.0 and 2.0% ephedrine were quantified by using high-speed (240 frames per second) digital microscopy combined with a beat-by-beat CBF analysis. At approximately 25 degrees C, we found that ephedrine induces an instant and moderate increase in human nasal CBF followed by an inhibitory response. With concentrations ranging from 0.25 to 2.0%, while the increment is independent of ephedrine concentration, the inhibitory effect is dependent on the concentration of ephedrine. Based on these results we propose that the clinically used concentration of ephedrine, 0.5%, has maximum stimulatory effect without obvious inhibitory effect on (cultured) human nasal CBF.

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Citations

Dec 17, 2014·American Journal of Rhinology & Allergy·Alan D Workman, Noam A Cohen
Jan 8, 2019·International Forum of Allergy & Rhinology·Vasiliki TriantafillouNoam A Cohen
Apr 21, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ke-Qing ZhaoNoam A Cohen
Feb 23, 2020·International Forum of Allergy & Rhinology·Vasiliki TriantafillouJohn V Bosso
Mar 27, 2019·Allergy, Asthma & Immunology Research·Jian Jiao, Luo Zhang
May 26, 2017·International Forum of Allergy & Rhinology·Alan D WorkmanNoam A Cohen
Apr 21, 2020·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Larisa TratnjekMateja Erdani Kreft
Oct 14, 2009·American Journal of Rhinology & Allergy·Demin HanLuo Zhang

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