Effects of epinephrine infusion on adipose tissue: interactions between blood flow and lipid metabolism

The American Journal of Physiology
J S SamraKeith Frayn

Abstract

Epinephrine has effects on both blood flow and metabolism in adipose tissue. To investigate how these effects might interact in vivo, epinephrine was infused into six healthy volunteers at a rate of 25 ng.kg-1.min-1. The rates of action of lipoprotein lipase and hormone-sensitive lipase in adipose tissue were calculated by measurement of arteriovenous differences across subcutaneous abdominal adipose tissue, and adipose tissue blood flow was measured. Epinephrine caused a significant rise in adipose tissue blood flow (P < 0.001), and the net efflux of nonesterified fatty acids (NEFA) from adipose tissue increased significantly (P < 0.05). Most of this efflux could be accounted for by hormone-sensitive lipase-derived NEFA efflux from cells (P < 0.05), but there was also a significant rise in the contribution of lipoprotein lipase-derived NEFA (P < 0.05). We conclude that adipose tissue blood flow plays an important role in the regulation of lipid metabolism, controlling substrate presentation for lipoprotein lipase and also preventing the local accumulation of fatty acids derived from both hormone-sensitive lipase and lipoprotein lipase.

References

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Citations

Feb 10, 2012·American Journal of Physiology. Endocrinology and Metabolism·Richard SotornikJean-Luc Ardilouze
Feb 14, 2002·Journal of Applied Physiology·Kai Henrik Wiborg LangeMichael Kjaer
Jul 24, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Anthony J DonatoLisa A Lesniewski
Dec 10, 2015·Nutrition Research Reviews·Monise Viana AbranchesMaria do Carmo Gouveia Peluzio
Aug 19, 2000·American Journal of Physiology. Endocrinology and Metabolism·L H EnevoldsenH Galbo
Apr 6, 2000·American Journal of Physiology. Endocrinology and Metabolism·R Mora-Rodriguez, E F Coyle
Mar 5, 2003·American Journal of Respiratory and Critical Care Medicine·Konstantin MayerFriedrich Grimminger
Oct 17, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Shane A PhillipsDavid D Gutterman
Jan 3, 2004·Journal of Lipid Research·May FarajKatherine Cianflone
May 29, 2000·American Journal of Physiology. Endocrinology and Metabolism·J F Horowitz, S Klein
Feb 3, 2012·Physiological Reviews·Dylan ThompsonKeith Frayn
Feb 25, 2021·Basic & Clinical Pharmacology & Toxicology·Anna Katrina Jógvansdóttir GradelHanne Hoffman Frølund Refsgaard

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