Effects of escin mixture from the seeds of Aesculus hippocastanum on obesity in mice fed a high fat diet

Pharmaceutical Biology
Gulcan AvciErdem Yesilada

Abstract

Escins, a triterpene glycoside mixture obtained from the ethanol extract of Aesculus hippocastanum L. (Hippocastanaceae) seed, was evaluated for its in vivo effects on the plasma levels of some hormones (leptin, insulin, FT(3), FT(4)) and biochemical parameters (glucose, triglyceride, total cholesterol, HDL-C, LDL-C concentrations) in mice fed with a high fat diet for 5 weeks. A high fat diet induced a remarkable increment in the plasma leptin (p <0.01), total cholesterol (p <0.01) and LDL-C (p <0.001) concentrations compared to control group animals. Combined administration of a high-fat diet with escins decreased leptin (31.6%) (p<0.05) and FT(4) (36.0%) (p<0.05) levels, increased HDL-C concentration (17.0%), while remained ineffective on LDL-C concentration in mice. Results have shown that escins may have beneficial effects in the understanding of obesity.

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Citations

Jul 11, 2020·Journal of Basic and Clinical Physiology and Pharmacology·Sahar IdrisMohd Khushtar
Feb 12, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Logesh RajanSuresh Kumar Mohankumar
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Avez SharipovJamoliddin Razzokov
Aug 13, 2021·Archives of Physiology and Biochemistry·Sachin V Suryavanshi, Yogesh A Kulkarni

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