PMID: 9526707Apr 4, 1998Paper

Effects of estradiol and an aromatase inhibitor on progesterone production in human cultured luteal cells

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
T EndoR Kudo

Abstract

The human corpus luteum produces both estradiol and progesterone. It is well known that there are both autocrine and paracrine systems for the regulation of the corpus luteum and that estradiol regulates the progesterone production of the corpora lutea of some other species. To assess the direct effects of estrogen on human luteal function, we performed cell culture experiments. A low concentration of estradiol, almost equal to the amount of estradiol produced by human cultured luteal cells, directly stimulated progesterone production. 4-Cyclohexylaniline, an aromatase inhibitor, significantly reduced both progesterone production and estradiol production. Levels of estradiol higher than the levels that cultured human luteal cells themselves produced significantly reduced basal progesterone production and also significantly reduced human chorionic gonadotropin (hCG), forskolin and dibutyryl-cyclic AMP-stimulated progesterone production. According to these data, high doses of estradiol produced a luteolytic action which widely inhibited the steroidogenesis process. In conclusion, our results indicated that estradiol in part regulates progesterone production physiologically and blocks progesterone production in a pharmacological o...Continue Reading

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Citations

Sep 21, 2002·Molecular and Cellular Endocrinology·Tommi E VaskivuoJuha S Tapanainen
Nov 14, 2003·Reproductive Biology and Endocrinology : RB&E·Kiyoshi Okuda, Ryosuke Sakumoto
Mar 10, 2004·The Journal of Reproduction and Development·Ryosuke Sakumoto, Kiyoshi Okuda
Mar 4, 2014·The Journal of Steroid Biochemistry and Molecular Biology·Ana C MoreiraVilma A Sardão
Jul 1, 2004·Reproduction in Domestic Animals = Zuchthygiene·B HoffmannP Papa
Nov 4, 2000·The Journal of Clinical Endocrinology and Metabolism·C H ChiangP C Leung
Jun 16, 2018·Reproduction, Fertility, and Development·Magali Del C de la VegaMarilina Casais
Mar 24, 2010·Fertility and Sterility·Anna TropeaRosanna Apa
Mar 11, 2003·Reproductive Biomedicine Online·Tommi E Vaskivuo, Juha S Tapanainen

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