PMID: 3747736Jul 1, 1986Paper

Effects of estradiol and environmental temperature changes on rat liver delta 6 microsomal desaturase activity

Lipids
S GonzalezR O Peluffo

Abstract

The regulation of delta 6 desaturase activity by environmental temperature changes was studied in the microsomal membranes from female and ovariectomized female rat liver. Female rats adapted at 30-32 C for 20-25 days and then shifted to 13-15 C for 5 days showed an increased delta 6 desaturase system. Ovariectomized rats adapted under the same conditions did not show significant changes in this enzyme. The fatty acid compositions of microsomal phosphatidylcholine showed a decrease in arachidonic acid in female rats at 30 C compared to females at 15 C and ovariectomized rats at both temperatures. These results suggest that a modification of ovaric sex hormone levels might be responsible for the different delta 6 desaturase activity in female rats acclimated at both temperatures. In this regard, serum estradiol radioimmunoassay yielded slight differences between the two groups of female rats, suggesting that estradiol could play a role in the regulation of the delta 6 desaturase. The administration of a pharmacological dose of 17-beta estradiol to female and ovariectomized rats kept at 30 and 15 C decreased the delta 6 microsomal desaturase activity. These data suggest that estradiol levels are involved in the regulation of the ...Continue Reading

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Citations

Jun 1, 1990·Biulleten' eksperimental'noĭ biologii i meditsiny·Iu A Bogdarin, N P Goncharov
Jan 23, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·María J T de Alaniz, Carlos Alberto Marra
Feb 1, 2008·The Proceedings of the Nutrition Society·Caroline E ChildsPhilip C Calder
Jan 1, 1987·Biotechnology & Genetic Engineering Reviews·S L Neidleman
Jun 6, 2003·Bioscience, Biotechnology, and Biochemistry·Yasuhiko ShimadaKimio Sugiyama
Mar 6, 2012·Animal Reproduction Science·C E GulliverE H Clayton
Sep 18, 2007·Journal of Hepatology·Ashraf Mohammad El-BadryPierre-Alain Clavien
Feb 24, 2006·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·María J BelliniRodolfo G Goya
Apr 6, 1988·Diabetes Research and Clinical Practice·J A BrignoneM C Susemihl
Nov 18, 2011·The American Journal of Clinical Nutrition·Tamás Decsi, Kathy Kennedy
Jul 26, 2021·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Hui Gyu ParkJ Thomas Brenna

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