Effects of estradiol and the angiotensin II receptor blocker irbesartan on vascular function in postmenopausal women

Menopause : the Journal of the North American Menopause Society
Faryal S MirzaEllen W Seely

Abstract

Estradiol and angiotensin receptor blockers have prominent effects on the renin-angiotensin-aldosterone system. The purpose of this study was to determine whether irbesartan, an angiotensin receptor blocker, has a greater effect on vascular function when combined with estradiol, compared with irbesartan alone, in hypertensive postmenopausal women. Fifty-one women were studied while off any antihypertensive medications or hormone therapy at baseline and after randomization to one of four treatment arms for 12 weeks: (1) irbesartan and estradiol, (2) irbesartan and placebo, (3) estradiol and placebo, and (4) placebo/placebo. Estradiol and placebo arms served as control groups. Blood pressure, brachial reactivity, aldosterone, insulin, glucose, 24-hour urinary catecholamines, urinary sodium, and creatinine were measured. Fisher's exact test was used for comparison of differences in blood pressure in the treatment arms. Paired t test and analysis of variance were also performed for within- and between-group analysis. A significantly larger number of women in the irbesartan and estradiol group had a decrease of 5 mm Hg or more in both systolic and diastolic blood pressures (P < 0.05) compared with irbesartan alone group. Forearm vas...Continue Reading

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Citations

Jan 10, 2008·Menopause : the Journal of the North American Menopause Society·Alfred O Mueck, Harald Seeger
Mar 16, 2012·Biology of Sex Differences·Kathryn Sandberg, Hong Ji
Aug 15, 2013·Menopause : the Journal of the North American Menopause Society·Catherine KimUNKNOWN Diabetes Prevention Program Research Group
Aug 19, 2015·Molecular and Cellular Endocrinology·Milan ObradovicEsma R Isenovic
Oct 1, 2014·Menopause : the Journal of the North American Menopause Society·Zeinab IssaGhada El-Hajj Fuleihan
Jun 29, 2010·Experimental Neurology·Ana I Rodriguez-PerezJose L Labandeira-Garcia
Mar 1, 2015·Drugs -- Real World Outcomes·James W Mold, Barbara J Holtzclaw
May 28, 2009·Hypertension·Matthias Barton, Matthias R Meyer
May 4, 2011·Hypertension·Matthias BartonEric R Prossnitz

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