Effects of estradiol on circulating P-selectin

The Journal of Clinical Endocrinology and Metabolism
B JilmaH G Eichler

Abstract

The membrane protein P-selectin tethers leukocytes to endothelial cells (EC) and on activated platelets, and may play a role in atherosclerosis. Lower plasma levels of a soluble (c) P-selectin have recently been observed in premenopausal women compared to those in men. Given the antiatherogenic-cardioprotective effect of 17 beta-estradiol (E2), we hypothesized that E2 may down-regulate the expression of P-selectin and subsequently decrease cP-selectin levels. The effects of E2 on levels of plasma cP-selectin were evaluated during the menstrual cycle in healthy women (n = 18) and by measuring the effect of a single im injection of 10 mg E2 valerate (n = 9) or placebo (n = 10) on cP-selectin levels in healthy male volunteers. In women, the cyclic increase in serum E2 concentrations was accompanied by a decrease in cP-selectin levels from 110 ng/mL [95% confidence interval (CI), 100-137 ng/mL] in the follicular phase. The decrease reached a maximum of 13% (95% CI, 2-19%, P = 0.014) in the luteal phase. In men, cP-selectin decreased from a median of 139 ng/mL (95% CI, 113-165) to 125 ng/mL (95% CI, 97-152; P = 0.038) 4 days after E2 injection. The median baseline value of cP-selectin in the 19 male volunteers was 133 ng/mL (95% CI,...Continue Reading

Citations

Nov 4, 2005·Biological Research for Nursing·Marguerite T Littleton-KearneyPatricia D Hurn
Nov 5, 1997·Contraception·M ShaarawyM Sheiba
Mar 6, 2009·Fertility and Sterility·Bulent O YildizHakan Yarali
Jun 21, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Muthuvel JayachandranVirginia M Miller

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