Effects of estradiol on the serotonin secretion and turnover in the hypothalamus of male tilapia, Oreochromis mossambicus, in vitro

General and Comparative Endocrinology
C L Tsai, L H Wang

Abstract

The effects of estradiol on the secretion and turnover of serotonin in the hypothalamic fragments of male tilapia, Oreochromis mossambicus, were studied using a static incubation system. The quantitative analysis of serotonin and its related metabolite, 5-hydroxyindoleacetic acid, were performed by high-performance liquid chromatography with electrochemical detection. The hypothalamic fragments were incubated with 17 beta-estradiol at a concentration of 2 x 10(-8), 8 x 10(-8), 2 x 10(-7), 4 x 10(-7), or 4 x 10(-6) g/ml. The low dose of estradiol, 2 x 10(-8) g/ml, had no effect on the concentration of serotonin and 5-hydroxyindoleacetic acid or serotonin turnover in the hypothalamic incubation media. The moderate doses of estradiol 8 x 10(-8) and 2 x 10(-7) g/ml, increased the concentrations of serotonin and 5-hydroxyindoleacetic acid in the hypothalamic incubation media, but had no effect on the serotonin turnover. The high doses of estradiol, 4 x 10(-7) and 4 x 10(-6) g/ml, did not alter the serotonin concentration in the hypothalamic incubation media, but increased the 5-hydroxyindoleacetic acid concentration and serotonin turnover. These results demonstrate that the moderate dose of estradiol increases the serotonin activity...Continue Reading

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Citations

Mar 17, 2004·Biochemical and Biophysical Research Communications·Yow-Ling ShiueChing-Lin Tsai
Dec 20, 2002·Endocrine Research·Francis SunnyOommen V Oommen
Jan 6, 2000·General and Comparative Endocrinology·C H SummersK J Renner

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