PMID: 8153130Jan 1, 1994Paper

Effects of estradiol on worm burden and peripheral leukocytes in Parastrongylus malaysiensis-infected rats

Parasitology Research
A B KamisM Z Badrul-Munir

Abstract

Gonadectomized male laboratory rats were given 0.06 mg/kg estradiol benzoate daily for 14 days before being inoculated with 50 third-stage larvae of Parastrongylus malaysiensis. Hormone treatment was continued until the rats were killed. The numbers of larvae in the brain and of adult worms in the pulmonary area of the rats were determined every 7 days after the inoculation. It was found that the rats treated daily with estradiol benzoate had significantly and consistently higher numbers of larvae and adult worms as compared with the controls. The number of total leukocytes increased significantly after the rats were infected. The results show that estradiol-treated rats become susceptible to P. malaysiensis infection, which may indicate that the immunosuppressive effects of testosterone observed in earlier studies may partly be caused by estradiol that was peripherally aromatized from testosterone.

References

Sep 1, 1992·Experimental Parasitology·W P BentenH Mossmann
Feb 1, 1990·Journal of Steroid Biochemistry·A H Schuurs, H A Verheul
Jan 1, 1984·International Journal of Immunopharmacology·R W LuebkeH T Hayes
May 1, 1983·Journal of Steroid Biochemistry·L DanelS Saez
May 1, 1982·Journal of Steroid Biochemistry·C J GrossmanG A Roselle

Related Concepts

estradiol-17 beta-benzoate
Metazoa
Brain
Aerodiol
Differential White Blood Cell Count Procedure
Lung
Orchiectomy
Testis
Testolin
Strongylida Infections

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