Effects of estro-progestagens on lipid and hormonal profiles in women with premature primary ovarian failure

Medicinski pregled
Maja IvanisevićMilka Drezgić

Abstract

Premature primary ovarian failure (PPOF) is defined as cessation of menstruation before the age of 40. Women with PPOF have hypergonadotropic amenorrhea and hypoestrogenia. The incidence of PPOF is 0.9-3%, and its etiology is multifactorial (genetic, enzyme deficit, virus infections, autoimmune diseases and idiopathic). PPOF is an independent risk factor for cardiovascular diseases. Untreated women are at higher risk for coronary disease, due to increase of total cholesterol, LDL, triglycerides and decrease of HDL. The aim of this investigation was to study effects of estro-progestagens on lipid and hormonal profiles in PPOF.: This tudy included: 30 healthy women aged 41+/-2.3 years; body mass index 25+/-3.2 kg; hip/waist ratio 0.76+/-0.04; amenorrheic for three years on average. Blood samples were taken for glycemia, cholesterol, HDL, LDL, FSH, LH, prolactin, estradiol, and progesterone measurement at 8 am, before and during the therapy with Trisequens. Hormone analysis: radioimmunoassay (RIA) (INEP, Zemun). Statistics. T-test and linear correlation. Total cholesterol, IIDL and LDL have decreased, while prolactin, estradiol and progesterone have increased significantly. Women receiving hormone replacement therapy (HRT) have re...Continue Reading

References

Jan 4, 1993·Atherosclerosis·J C StevensonI F Godsland
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Oct 4, 2002·Maturitas·Amos Pines

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Citations

Jun 10, 2014·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Pantelis TsimarisGeorge Creatsas

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