PMID: 9187541Feb 1, 1997Paper

Effects of estrogen on cell growth and fibroblast growth factor receptor induction in MtT/Se cells

Endocrine Research
H Takahashi, S Nakagawa

Abstract

The effects of estradiol (E2) on cell growth and the expression of fibroblast growth factor receptor (FGFR) were investigated in a cultured rat anterior pituitary cell line (MtT/Se) established from an E2-induced mammotropic pituitary tumor. E2 stimulated cell growth 2-3 fold as compared to the control. Basic fibroblast growth factor (bFGF) stimulated cell growth in the presence of E2 (10(-9) M) but not in the absence of E2. Tamoxifen as an antiestrogen agent inhibited the proliferation of MtT/Se cells which had been treated with E2 or E2 and bFGF. Numbers of FGFR in E2-stimulated MtT/Se cells significantly exceeded those in cells not treated with E2. These observations indicate that E2 plays an important role in the regulation of FGFR induction in the anterior pituitary cells.

References

Mar 1, 1988·Molecular Endocrinology·R B LinghamD S Loose-Mitchell
Jul 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·K A Elias, R I Weiner
Jul 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·B E Summer, G Fink
Feb 1, 1993·Proceedings of the Society for Experimental Biology and Medicine·K ZhangR V Lloyd

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Citations

Jul 12, 2002·Journal of the American Geriatrics Society·Maria Clara M PaderoTheodore C Friedman
Jul 30, 2002·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Diana B PetittiVicki Chiu
Apr 25, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P D Hurn, I M Macrae
Oct 6, 2001·Frontiers in Neuroendocrinology·S Hentges, D K Sarkar

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