Effects of estrogen on circulating "free" and total 1,25-dihydroxyvitamin D and on the parathyroid-vitamin D axis in postmenopausal women

The Journal of Clinical Investigation
C CheemaR Marcus

Abstract

We evaluated the effect of estrogens on "free" and total calcitriol levels and on the calcitriol response to a hypocalcemic challenge in 12 postmenopausal women, age 55-74 yr. Endogenous calcitriol production was induced by intravenous Na-EDTA before and after conjugated estrogens, 1.25 mg/d for 30 d. Free calcitriol was determined by centrifugal ultrafiltration and by the molar ratio of calcitriol to vitamin D-binding protein (DBP). Estrogen increased fasting total calcitriol from 38.5 +/- 3.8 to 62.3 +/- 7.0 pg/ml (P less than 0.05). This was accompanied by a rise in free calcitriol from 104.5 +/- 11.4 to 158.7 +/- 16.4 fg/ml (P less than 0.05). Vitamin D-binding protein increased from 348 +/- 16 to 428 +/- 12 micrograms/ml (P less than 0.001), and the ratio of calcitriol/DBP increased from 1.50 +/- 0.14 to 1.94 +/- 0.18 (P less than 0.005), confirming the rise in free calcitriol. Increases in free calcitriol and in calcitriol/DBP ratios were significantly correlated, r = 0.72. Hypocalcemia led to a rapid increase in circulating immunoreactive parathyroid hormone, and to a rise in calcitriol at 24 h. The hypocalcemia-induced rise in total and free calcitriol was similar before and after estrogen, whether expressed as incremen...Continue Reading

References

Feb 1, 1975·The Journal of Clinical Investigation·D D Bikle, H Rasmussen
Feb 1, 1979·The Journal of Clinical Investigation·R KumarF H Epstein
Aug 1, 1977·The Journal of Clinical Endocrinology and Metabolism·R BouillonP de Moor
Oct 1, 1977·The Journal of Clinical Endocrinology and Metabolism·R BouillonP De Moor
Aug 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·Y TanakaH F DeLuca
Sep 1, 1986·Calcified Tissue International·J R BuchananL M Demers
Jul 1, 1988·The Journal of Clinical Endocrinology and Metabolism·K W LylesB Lobaugh
Oct 1, 1987·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M S ForeroB L Riggs
Oct 1, 1987·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·G YoungG V Segre
Dec 1, 1980·The Journal of Clinical Endocrinology and Metabolism·J C GallagherH F DeLuca
Jun 1, 1984·The Journal of Clinical Investigation·K S TsaiB L Riggs
Apr 1, 1983·The Journal of Clinical Endocrinology and Metabolism·S C ManolagasL J Deftos
Jan 1, 1984·The Journal of Clinical Endocrinology and Metabolism·T A ReinhardtB W Hollis
Aug 13, 1981·The New England Journal of Medicine·D M SlovikJ T Potts

❮ Previous
Next ❯

Citations

Jun 1, 1997·Journal of Cellular Biochemistry·R A CriddleR L Prince
Aug 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E PackerR Marcus
May 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·B Dawson-HughesG E Dallal
Jul 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K K Ho, A J Weissberger
Jun 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R L PrinceA St John
Oct 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H K KinyamuK L Ryschon
Jan 1, 1991·Calcified Tissue International·C Lamberg-Allardt
Oct 14, 1994·Clinica Chimica Acta; International Journal of Clinical Chemistry·S C HoR Swaminathan
Oct 1, 1990·The Journal of Steroid Biochemistry and Molecular Biology·L P Schot, A H Schuurs
Nov 30, 1990·The Journal of Steroid Biochemistry and Molecular Biology·D SömjenA M Kaye
Mar 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·J Verhaeghe, R Bouillon
Sep 1, 1996·Bone·I Zofková, R L Kancheva
May 6, 2003·Bioscience, Biotechnology, and Biochemistry·Hajime TamakiIsao Chinen
Jun 4, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·B L RiggsL J Melton
Jan 20, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E M ColinJ P Van Leeuwen
Oct 4, 2012·Journal of Periodontology·Daniel JönssonRyan T Demmer
Dec 1, 1994·Calcified Tissue International·H J van HoofT J Benraad
Jul 1, 1992·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S AdamiV Lo Cascio
Mar 14, 2013·Expert Opinion on Medical Diagnostics·Noel G Carlson, John W Rose
Dec 4, 2012·Maturitas·H C J P JanssenY T van der Schouw
Jul 4, 2012·Maturitas·H C J P JanssenY T van der Schouw
Nov 9, 2010·Fertility and Sterility·Giulio DisantoSreeram V Ramagopalan
Dec 3, 2014·The International Journal of Eating Disorders·Nicola VeroneseChristoph U Correll
Dec 9, 2014·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Sudhindra M Bhattacharya, Mainak Ghosh
Jun 30, 2015·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·L Claudia PopXiangbing Wang
Aug 29, 2012·Dermato-endocrinology·Uwe Gröber, Klaus Kisters
May 24, 2016·The Journal of Steroid Biochemistry and Molecular Biology·Andrea Olmos-OrtizLorenza Díaz
Apr 1, 1994·The American Journal of Medicine·N H BellR G Russell
Jul 1, 2016·The Journal of Obstetrics and Gynaecology Research·Deepti GoswamiVishnubhatla Sreenivas
Sep 28, 2010·Journal of Oncology·Qamar J KhanPriyanka Sharma
Mar 11, 2003·Menopause : the Journal of the North American Menopause Society·Ann VincentSundeep Khosla

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved