Effects of estrogen on estrogen receptor expression in the bursal cells of chick embryos and steroidogenic enzymes gene expression in the bursa: relevance of estrogen receptor and estrogen synthesis in the bursa of chick embryos

Animal Science Journal = Nihon Chikusan Gakkaihō
Young-Ha ShinYasuhiro Kondo

Abstract

Estrogen has been reported to act on B cell genesis in the bursa of Fabricius of chick embryos. In this study, we attempted to demonstrate the hypothesis that B cell genesis is controlled by estrogen receptor (ER) in the bursal cells and steroidogenic enzymes synthesized in the bursa. We previously reported the presence of estrogen receptor α (ERα) in the bursa during the late stage of embryogenesis and an increase in the expression of ERα messenger RNA (mRNA) between the 13th day and 16th day. The number of ER-positive cells was maximal on the 16th day. In the present study, ER-positive cells in the bursa during the late stage of embryogenesis increased 4 h after β-estradiol treatment on the 14th to 18th day. The concentration of β-estradiol in the embryonic bursa increased. These results suggest that this stage of embryogenesis is critical in B cell development in the bursa in connection with the effect of estrogen treatment. Our findings also showed that the mRNA expression of five steroidogenic enzymes occurred in the bursa of chick embryos. These results suggest that estrogen is synthesized in the embryonic bursa and estrogen acts on the bursal cells in a paracrine fashion.

References

Oct 1, 1987·Nihon juigaku zasshi. The Japanese journal of veterinary science·Y KondoK Sato
Jan 1, 1995·The Journal of Experimental Medicine·E ParamithiotisM J Ratcliffe
Apr 1, 1993·Immunology Letters·K SorachiH Imura
Feb 5, 2000·The Journal of Steroid Biochemistry and Molecular Biology·O NomuraS Mizuno
Aug 11, 2004·General and Comparative Endocrinology·Ryo KamataMasatoshi Morita

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Citations

Sep 5, 2013·Animal Science Journal = Nihon Chikusan Gakkaihō·Masafumi KatayamaYasuhiro Kondo

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