Effects of estrogen or testosterone on self-reported sexual responses and behaviors in hypogonadal adolescents

The Journal of Clinical Endocrinology and Metabolism
J W FinkelsteinH E Kulin

Abstract

The purpose of this study was to investigate the effects of administration of sex steroids on self-reported sexual responses and behaviors in hypogonadal adolescents. We used a randomized, double blind, placebo-controlled, cross-over, clinical trial as the experimental design. The subjects were 39 boys and 16 girls with delayed puberty. We treated girls with oral conjugated estrogen and boys with testosterone enanthate in 3 dose levels intended to simulate early, middle, and late pubertal levels. We administered a modification of the Udry sexual behavior questionnaire after each 3-month placebo and treatment period to detect the effect of sex steroids on self-reported sexual behaviors and responses. We employed a strict intent to treat statistical analytical model. The data showed significant effects of the administration of testosterone to boys causing increases in nocturnal emission and touching behaviors at the mid- and high doses. No other treatment effects on sexual behaviors or responses were seen in boys. For girls, there was a significant increase in necking caused by the administration of estrogen only at the late pubertal dose. No other treatment effects on sexual behaviors or responses were seen in girls. We noted so...Continue Reading

Citations

Dec 31, 2010·Journal of Youth and Adolescence·Sonya NegriffPenelope K Trickett
Mar 21, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Peter J SchmidtDavid R Rubinow
Apr 15, 2004·European Urology·Antonio AversaAndrea Fabbri
Jul 8, 2015·The Journal of School Health·Ahna Ballonoff SuleimanAdriana Galván
Jan 15, 2013·American Journal of Obstetrics and Gynecology·Cristina RosCamil Castelo-Branco
Sep 29, 2000·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·L F O'SullivanB X Watkins
Oct 11, 2016·Developmental Cognitive Neuroscience·Ahna Ballonoff SuleimanRonald E Dahl
Mar 13, 2018·Aggressive Behavior·Fabian ProbstJanek S Lobmaier
Dec 23, 2006·Archives of Sexual Behavior·Carolyn T HalpernDenise D Hallfors

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