PMID: 9443943Jan 28, 1998Paper

Effects of ethanol and anesthetics on type 1 and 5 metabotropic glutamate receptors expressed in Xenopus laevis oocytes

Molecular Pharmacology
K MinamiR A Harris

Abstract

Previous studies have demonstrated that ethanol and volatile anesthetics inhibit the function of some metabotropic (G protein-coupled) receptors, including the 5-hydroxytryptamine2 and muscarinic cholinergic receptors. The metabotropic glutamate receptors (mGluRs) show little sequence homology with most other metabotropic receptors and are important modulators of synaptic transmission in the mammalian central nervous system. It was of interest to determine drug actions on these receptors, and we investigated the effects of ethanol, halothane, the anesthetic compound F3 (1-chloro-1,2,2-trifluorocyclobutane), and the nonanesthetics F6 (1,2-dichlorohexafluorocyclobutane) and F8 (2,3-chlorooctafluorobutane) on the function of mGluR1 and mGluR5 expressed in Xenopus laevis oocytes. Halothane, F3, and ethanol inhibited mGluR5-induced Ca(2+)-dependent Cl- currents, yet pharmacologically relevant concentrations of these compounds had little effect on the glutamate-induced currents in the oocytes expressing mGluR1. F6 had inhibitory effects on both receptors, and F8 did not affect either mGluR1 or mGluR5 function. The protein kinase C (PKC) inhibitor GF109203X enhanced the glutamate-induced current, and the PKC activator phorbol-12-myris...Continue Reading

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Citations

Apr 19, 2002·Molecular Pharmacology·Yumiko IshizawaRoderic G Eckenhoff
Dec 15, 2004·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Elzbieta WrobelAnna Scinska
Mar 24, 2007·Journal of Pharmacological Sciences·Kouichiro MinamiYoichi Ueta
Mar 18, 2008·Alcoholism, Clinical and Experimental Research·Zuzana Kapasova, Karen K Szumlinski
Oct 17, 2008·Journal of Neurophysiology·Amor BelmeguenaiChristian Hansel
Mar 5, 2011·Journal of Pharmacological Sciences·Kouichiro MinamiYasuhito Uezono
Sep 14, 2011·Pharmacology·Kouichiro MinamiYasuhito Uezono
May 4, 2012·Alcoholism, Clinical and Experimental Research·Devesh MishraKarima Chergui
Jan 30, 2008·Alcoholism, Clinical and Experimental Research·Matthew T ReillyR Adron Harris
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May 1, 2018·Frontiers in Neuroscience·Rashidi M Pakri MohamedJaya Kumar
Mar 27, 2001·Annual Review of Pharmacology and Toxicology·T YamakuraR A Harris
Oct 23, 2002·Molecular Pharmacology·Michael F WilkemeyerMichael E Charness
Dec 20, 2003·Annals of the New York Academy of Sciences·Karen K SzumlinskiPeter W Kalivas
May 2, 2003·British Journal of Pharmacology·Hui-Fang LiJoan J Kendig
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Jul 21, 2020·Bioelectricity·Vaibhav P Pai, Dany Spencer Adams
Jan 5, 2002·Anesthesia and Analgesia·Kouichiro MinamiAkio Shigematsu
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Oct 27, 2012·Journal of Anesthesia·Kouichiro Minami, Yasuhito Uezono
Oct 24, 1998·British Journal of Pharmacology·M P MasciaR A Harris
Nov 19, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Joyce Besheer, Clyde W Hodge

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