Effects of ethanol concentration and fixed-ratio requirement on ethanol self-administration by P rats in a continuous access situation

Alcoholism, Clinical and Experimental Research
F J FilesH H Samson

Abstract

Rats, from the alcohol preferring (P) line, were placed in operant chambers in which food pellets, water, and 10% ethanol (v/v) were available continuously for 23 hr/day. During Experiment 1, the effects of changing ethanol concentration and response requirement for ethanol were examined. Ten percent and 20% ethanol (v/v) were available on two fixed ratio (FR) schedules, FR 1 and FR 4, for 2 weeks each. During Experiment 2, the effects of increasing the response requirement for ethanol were investigated. Starting with FR 4, the FR requirement for ethanol doubled during 2-week intervals until FR 32 was in effect. For the final phase of these studies, water was placed in the dipper for 1 week followed by a return to 10% ethanol in the dipper. The results from Experiment 1 indicated that when the FR requirement was decreased from FR 4 to FR 1, ethanol-reinforced responding decreased but total daily intake increased. Lowering the FR requirement did not affect the number of ethanol bouts per day but bout size increased. Ethanol concentration had no effect on bout size but the number of bouts per day decreased when the concentration was increased to 20%. Since bout size was unchanged by increasing the ethanol concentration, intake pe...Continue Reading

References

Aug 1, 1992·Alcoholism, Clinical and Experimental Research·F J FilesT K Li
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Citations

Mar 27, 2001·Pharmacology, Biochemistry, and Behavior·K Ackroff, A Sclafani
Oct 12, 2002·Pharmacology, Biochemistry, and Behavior·Karen Ackroff, Anthony Sclafani
Jul 14, 1999·Behavioural Brain Research·F O RisingerA C Vickrey
Mar 27, 2003·Alcohol·Amanda L Sharpe, Herman H Samson
Feb 16, 2013·Behavioural Pharmacology·Geoffrey W PeitzMark A Smith
Jun 11, 1998·Alcoholism, Clinical and Experimental Research·F O RisingerR A Oakes
Jan 12, 1999·Alcoholism, Clinical and Experimental Research·S F LogueJ M Wehner
Nov 23, 2006·Alcoholism, Clinical and Experimental Research·Elise M WeertsRobert D Hienz
Apr 22, 2008·Alcoholism, Clinical and Experimental Research·Barbara J KaminskiElise M Weerts
Jan 31, 2006·Pharmacology, Biochemistry, and Behavior·Richard L BellWilliam J McBride
Jul 11, 2000·Alcoholism, Clinical and Experimental Research·H H SamsonC J Slawecki
Oct 1, 1995·Alcoholism, Clinical and Experimental Research·F J FilesG T Brice
Feb 9, 2006·Journal of Health Psychology·Jane CherringtonJoe Grixti
May 15, 2003·Journal of Health Communication·Gina Agostinelli, Joel W Grube

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