PMID: 7087687Mar 1, 1982Paper

Effects of ethanol diets on cholesterol content and phospholipid acyl composition of rat hepatocytes

Lipids
T L SmithM J Gerhart

Abstract

Chronic treatment of adult male rats with ethanol liquid diets resulted in alterations in phospholipid and cholesterol contents as well as the acyl composition of phosphatidylethanolamine (PE), phosphatidylinositol (PI)-phosphatidylserine (PS) mixture, and phosphatidylcholine (PC) of isolated hepatocytes. The influence of ethanol on these lipids was largely dependent on the proportion of dietary fat. Phospholipid and total cholesterol contents were elevated 23 and 27%, respectively, by ethanol when offered in a low-fat diet (5% corn oil). Only the percentage of arachidonic acid from PI-PS was significantly reduced in the low-fat ethanol group. Exposure to a high-fat (34% corn oil) diet in the presence of ethanol for 4-5 weeks resulted in a significant decrease in arachidonate/linoleate ratios of hepatic PE, PS-PI and PC, while total phospholipid content remained constant. In the high-fat, ethanol-treated group, hepatic cholesterol content was increased 2-fold. These results suggest that the level of dietary fat plays an important role in determining the effects of chronic ethanol consumption on hepatic cholesterol content and phospholipid acyl composition.

References

Nov 16, 1978·Biochimica Et Biophysica Acta·J H ChinD B Goldstein
Jul 1, 1976·Biochemical Pharmacology·J S Hayes, K Brendel
Jan 1, 1975·Advances in Experimental Medicine and Biology·M W Hill, A D Bangham
Dec 17, 1969·Biochimica Et Biophysica Acta·C L MendenhallR H Furman
Jan 1, 1967·Acta Chemica Scandinavica·O A Forsander, K O Lindros
Apr 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·A J WaringE Rubin
Jun 1, 1965·The Journal of Clinical Investigation·C S LieberL M DECARLI

Citations

Jan 1, 1983·Pharmacology, Biochemistry, and Behavior·E Anggård
Dec 1, 1985·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S Baldwin, R S Parker
Mar 1, 1985·Alcoholism, Clinical and Experimental Research·G Y Sun, A Y Sun
Jan 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F J FieldD R LaBrecque
Jan 1, 1987·Annals of the New York Academy of Sciences·D B Goldstein
Jan 1, 1987·Annals of the New York Academy of Sciences·H Rottenberg
Aug 1, 1997·Seizure : the Journal of the British Epilepsy Association·C Y Tan, D F Weaver
Feb 1, 1987·Alcoholism, Clinical and Experimental Research·D Horrobin
Feb 1, 1987·Alcoholism, Clinical and Experimental Research·A WolkinJ Rotrosen

Related Concepts

Ethanol
Metazoa
Epicholesterol
Diet
Saturated Fat
Liver
Phosphatidylcholines
Phosphatidylethanolamines
Phosphatidylinositols
Phospholipids

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Generating Insulin-Secreting Cells

Reprogramming cells or using induced pluripotent stem cells to generate insulin-secreting cells has significant therapeutic implications for diabetics. Here is the latest research on generation of insulin-secreting cells.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Epigenome Editing

Epigenome editing is the directed modification of epigenetic marks on chromatin at specified loci. This tool has many applications in research as well as in the clinic. Find the latest research on epigenome editing here.