Effects of ethanol during the onset of female puberty

Neuroendocrinology
W L Dees, C W Skelley

Abstract

To assess more closely the physiological mechanism(s) by which ethanol (ETOH) delays the onset of female puberty, we have evaluated its effects on body weight, the vaginal opening (VO)-first diestrus (D1) interval and the serum concentrations of growth hormone (GH), luteinizing hormone (LH) and follicle-stimulating hormone (FSH) throughout the peripubertal period in the rat. Using a specific intragastric feeding regimen, 29-day-old rats began receiving either a liquid diet containing ETOH or an isocaloric control liquid diet. Additional controls consisted of animals maintained on laboratory chow and water provided ad libitum. Animals were either killed between 32 and 37 days of age, categorized with regard to their phase of puberty and their serum hormones measured; or, in some animals, the ETOH liquid diet was administered through day 41 and at that time replaced by the control liquid diet in order to determine if recovery would occur. Our results indicate that ETOH-treated animals showed significantly lower body weights and a significantly longer mean VO-D1 interval than the control animals. Also, serum GH and LH levels were significantly lower in the ETOH-treated animals; however, FSH levels were not affected. Administration...Continue Reading

Citations

May 17, 2005·Brain Research. Molecular Brain Research·Hyun Joon KimGyeong Jae Cho
May 22, 2003·Neurotoxicology and Teratology·Robert F Smith
Dec 23, 1999·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·I F Litt
Sep 3, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Vinod K SrivastavaWilliam L Dees
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Jun 13, 2009·Alcoholism, Clinical and Experimental Research·Vinod K SrivastavaW Les Dees
Nov 13, 2019·Journal of Neuroendocrinology·William L DeesVinod K Srivastava

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