Effects of ethanol on hippocampal function during adolescence: a look at the past and thoughts on the future

Alcohol
Vivien S ChinD B Matthews

Abstract

It has been demonstrated by several laboratories that ethanol, both acute and chronic, produces effects that are age dependent. Specifically, adolescent rats are less sensitive to the hypnotic and motor-impairing effects of ethanol but are more sensitive to the hypothermic effects of the drug. However, the results on hippocampal function are not as clear. For example, there have been mixed findings regarding adolescent sensitivity of hippocampal-dependent (spatial) memory in response to ethanol. The current review explores the present state of the field as it relates to ethanol's effects in the hippocampus, particularly as it relates to spatial memory. In addition, we review potential neurobiological mechanisms that might underlie the age-dependent effects of ethanol in the hippocampus. Finally, future directions are proposed that will advance the state of the field as it relates to ethanol's effect during this developmental period.

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Citations

Sep 1, 2011·The Journal of Biological Chemistry·Sanjay YadavDevendra Parmar
Mar 19, 2013·Addictive Behaviors·Justine A GrossoFiona S Graff
Sep 5, 2012·Alcohol·Luis M García-Moreno, Jose M Cimadevilla
Apr 5, 2013·Alcoholism, Clinical and Experimental Research·Adelle NovierDouglas B Matthews
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May 18, 2011·Alcoholism, Clinical and Experimental Research·María ParadaFernando Cadaveira
Mar 22, 2012·Alcoholism, Clinical and Experimental Research·Chiming HuangRosa Huang
Aug 27, 2014·Alcoholism, Clinical and Experimental Research·Lindsay M SquegliaDouglas B Matthews
Jun 22, 2012·Behavioral and Brain Functions : BBF·Antonio Vidal-InferMarta Rodríguez-Arias
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Apr 7, 2015·Pharmacology, Biochemistry, and Behavior·Adelle NovierDouglas B Matthews
Dec 3, 2014·Behavioural Processes·Jennifer T SneiderMarisa M Silveri
Apr 16, 2019·Annals of Internal Medicine·Ryan A CrowleyUNKNOWN Health and Public Policy Committee of the American College of Physicians
Oct 25, 2017·Chemical Research in Toxicology·Ana ContrerasCarmen Pérez-García

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