PMID: 7539684Apr 1, 1995Paper

Effects of ethanol on the pancreas of disulfiram-treated rats

Journal of Gastroenterology
S HondaM Nasu

Abstract

To study the effects of ethanol on disulfiram-treated rats, we administered ethanol orally at a does of 2000 mg/kg, twice daily for 5 days. The administration of ethanol or disulfiram alone produced no recognizable changes in pancreatic acinar cells. Ethanol administration, in disulfiram-treated rats resulted in a decrease in the content of zymogen granules in acinar cells, and the appearance of intraplasmic vacuolization. Electron microscopically, these vacuoles appeared on the basal side of nuclei. In addition, similar vacuoles appeared in liver cells, and these vacuolizations seemed to show lipid inclusions. However, ethanol administration to disulfiram-treated rats did not cause inflammatory changes or edema in the pancreas. A comparison of blood ethanol levels in rats receiving ethanol alone and disulfiram plus ethanol showed no significant difference, but acetaldehyde levels in rats receiving ethanol plus disulfiram rats were significantly higher than those in rats receiving ethanol alone. These findings suggested that acetaldehyde caused a decrease of zymogen granules and the presence of lipid inclusions in pancreatic acinar cells.

References

Mar 11, 1977·Virchows Archiv. A, Pathological Anatomy and Histology·M Lampel, H F Kern
May 14, 1979·Virchows Archiv. A, Pathological Anatomy and Histology·G AdlerH F Kern
Dec 1, 1991·Annals of Surgery·I H NordbackJ L Cameron
Apr 1, 1990·Gastroenterology·M Singh, H Simsek
Jun 1, 1983·Australian and New Zealand Journal of Medicine·J S Wilson, R C Pirola
Jan 1, 1984·The Medical Clinics of North America·M C Geokas
Nov 1, 1982·Digestive Diseases and Sciences·G AdlerH F Kern

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Citations

Sep 25, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·E Madrigal-BujaidarG Chamorro
Sep 27, 2014·Journal of Sports Sciences·Claudiane Arakaki FukuchiDarren John Stefanyshyn
Jan 31, 2008·Physiotherapy Research International : the Journal for Researchers and Clinicians in Physical Therapy·Thomas W KernozekChristopher J Durall

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