Effects of ethinyl estradiol, estradiol, and testosterone on hindlimb endothelial function in vivo

Journal of Cardiovascular Pharmacology
Rabelais Tatchum-TalomAndré Marette

Abstract

This study was designed to evaluate the effects of chronic treatment with estrogen and testosterone on hindlimb vascular function. Spontaneously hypertensive rats (SHR) were sham-operated (SHAM) or ovariectomized and treated with vehicle (OVX), ethinyl estradiol (OVX-EE2), estradiol (OVX-E2), or testosterone (OVX-TESTO) for 3 weeks. Anesthetized SHR were instrumented for the measurement of arterial blood pressure and hindlimb blood flow. Ovariectomy had no significant effect on hindlimb resistance. Resting blood pressure (mm Hg) and hindlimb resistance (mm Hg/ml/min/kg) were higher in OVX-TESTO (158 +/- 4 and 4.7 +/- 0.3) than SHAM control (130 +/- 6 and 3.3 +/- 0.4), OVX (139 +/- 6 and 3.4 +/- 0.3), OVX-EE2 (130 +/- 4 and 3.0 +/- 0.3), and OVX-E2 (120 +/- 4 and 3.3 +/- 0.4). The hemodynamic responses to the endothelium-dependent vasodilator acetylcholine (ACh) were similar in SHAM, OVX, OVX-EE2, and OVX-E2. The hindlimb vasodilatory effects of ACh were consistently greater in OVX-TESTO compared with OVX, OVX-EE2, OVX-E2, and SHAM control rats. The hemodynamic responses to the nitric oxide donor, sodium nitroprusside, were similar in all groups. Our results provide evidence of modulatory influence of testosterone on vasomotor f...Continue Reading

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Citations

Sep 15, 2005·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hisako KameyamaSusumu Sasaki
May 16, 2008·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Budbazar EnkhjargalYasushi Sakai
Dec 17, 2008·Women's Health·Charikleia D Christakou, Evanthia Diamanti-Kandarakis
Apr 8, 2004·Biological Research for Nursing·Marguerite Littleton-Kearney, Patricia D Hurn

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