PMID: 6159794Nov 1, 1980Paper

Effects of ethionine on digestive enzyme synthesis and discharge by mouse pancreas

The American Journal of Physiology
L Gilliland, M L Steer

Abstract

The earliest changes noted during the evolution of pancreatitis induced by feeding mice a choline-deficient ethionine-supplemented (CDE) diet are an increase in the number of zymogen granules in pancreatic acinar cells and an increase in digestive enzyme content of the pancreas. We have studied the processes of protein and digestive enzyme synthesis and discharge at varying times after institution of the CDE diet, a choline-deficient diet (CD), and a diet containing ethionine but not choline-deficient (E). Both the CDE and E diets increased digestive enzyme content within 12 h of their institution. Both the CDE and E diets reduced the rate of protein and amylase synthesis and caused a marked reduction in the rate of protein and amylase discharge from the pancreas. These changes were greatest and were noted earliest in the CDE diet group. A marked reduction in secretagogue-induced in vivo and in vitro amylase discharge followed ingestion of either the CDE or E diet. These studies indicate that the increased pancreatic content of digestive enzymes noted after ingestion of the CDE and E diets results from an ethionine-induced decrease in the rat of digestive enzyme discharge. This phenomenon is enhanced by simultaneous choline def...Continue Reading

Citations

May 30, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Maria Dolors SansJohn A Williams
Jun 12, 2019·International Journal of Molecular Sciences·Pedro Silva-VazJosé Guilherme Tralhão
Jul 28, 2010·Experimental Animals·Satoshi IdaKen-ichi Yamamura

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