PMID: 16634330Apr 26, 2006Paper

Effects of excess corticosterone on NADPH generating enzymes and glucose oxidation in Leydig cells of adult rats

Human & Experimental Toxicology
T Subramanian KavithaKarundevi Balasubramanian

Abstract

Clinical and experimental studies have shown the adverse effects of excess glucocorticoid on testicular testosterone production. The NADPH co-enzyme has been recognized as an important factor that regulates several steps in steroidogenesis, while glucose oxidation acts as a limiting factor on testicular testosterone production. Nevertheless, the impact of excess corticosterone, the stress hormone on testicular NADPH availability and glucose oxidation is unknown. Therefore, the present study was designed to assess the specific effects of excess corticosterone on Leydig cell NADPH generating enzymes and glucose oxidation. Adult Wistar rats (200-250 g, b.w.) were treated with corticosterone-21-acetate (2 mg/ 100 g, b.w., i.m., twice daily) for 10 days and corticosterone-21-acetate plus luteinizing hormone (LH) (100 microg/kg b.w., i.m., daily) for 10 days. After the treatment period, experimental animals and controls were killed, blood was collected and the sera separated for testosterone assay. Testes were removed and Leydig cells were isolated, purified and used for estimating the specific activity of NADPH generating enzymes and 14C-glucose oxidation. Serum testosterone, Leydig cellular 14C-glucose oxidation and the specific ac...Continue Reading

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Citations

Dec 15, 2006·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·R BadrinarayananK Balasubramanian
Jan 22, 2013·General and Comparative Endocrinology·Sophie RettenbacherMichael Lepschy
Aug 29, 2006·Ecotoxicology and Environmental Safety·Tannia GraciaJohn P Giesy
Jun 25, 2015·Acta Cirúrgica Brasileira·Flávia Cristina Morone PintoFrancisco José Barcellos Sampaio
Jun 29, 2011·Kidney & Blood Pressure Research·Diogo Benchimol de SouzaCélia Martins Cortez
Oct 30, 2014·Acta Cirúrgica Brasileira·Gisele S RibeiroFrancisco J B Sampaio

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