Effects of excess pantothenic acid administration on the other water-soluble vitamin metabolisms in rats

Journal of Nutritional Science and Vitaminology
Katsumi ShibataRyuzo Sasaki

Abstract

To acquire the data concerning the tolerable upper intake level which prevents health problems from an excessive intake of pantothenic acid, an animal experiment was done. Rats of the Wistar strain (male, 3 wk old) were fed on a diet which contains 0%, 0.0016% (control group), 1%, or 3% calcium pantothenate for 29 d. The amount of weight increase, the food intake, and the organ weights were measured, as well as the pantothenic acid contents in urine, the liver and blood. Moreover, to learn the influence of excessive pantothenic acid on other water-soluble vitamin metabolism, thiamin, riboflavin, a vitamin B6 catabolite, the niacin catabolites, and ascorbic acid in urine were measured. As for the 3% addition group, enlargement of the testis, diarrhea, and hair damage were observed, and the amount of weight increase and the food intake were less than those of the control group. However, abnormality was not seen in the 1% addition group. The amount of pantothenic acid in urine, the liver, and blood showed a high correlation with intake level of pantothenic acid. It was only for 4-pyridoxic acid, a vitamin B6 catabolite, in urine that a remarkable difference was observed against the control group. Moreover, the (2-Py+4-Py)/MNA excr...Continue Reading

Citations

May 14, 2009·Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan·Tsutomu FukuwatariKatsumi Shibata
May 14, 2009·Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan·Tsutomu FukuwatariKatsumi Shibata
May 14, 2009·Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan·Tsutomu FukuwatariKatsumi Shibata
Sep 26, 2015·Digestive Diseases and Sciences·Mariana Verdelho MachadoAnna Mae Diehl
Dec 5, 2009·The Journal of Veterinary Medical Science·Tatsuya YAMAMOTOKazuyoshi TAYA
Jan 1, 2013·Nutrition and Metabolic Insights·Katsumi ShibataTsutomu Fukuwatari
Aug 4, 2018·Indian Journal of Clinical Biochemistry : IJCB·Shedid SmHammad As

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