Effects of Excessive Iodine Intake on Blood Glucose, Blood Pressure, and Blood Lipids in Adults

Biological Trace Element Research
Jiwei LiuHongmei Shen

Abstract

To understand the effects of excess iodine intake on blood glucose, blood pressure, and blood lipids in adults. We selected three villages from Shanxi Province to conduct cross-sectional survey: Maxi [median water iodine concentration (MWIC) 6.3 μg/L, median urinary iodine concentration (MUIC) 126.6 μg/L, 320 adults]; Xiwenzhuang (MWIC 79.8 μg/L, MUIC 221.2 μg/L, 264 adults); and Gaoche (MWIC 506.0 μg/L, MUIC 421.3 μg/L, 241 adults). According to the urinary iodine levels in adults, the three villages were defined as iodine-adequate, iodine-sufficient, and iodine-excess. Urinary iodine, water iodine, thyroid function, blood glucose, blood pressure, and blood lipids were measured. Compared with the iodine-adequate area, blood glucose and systolic and diastolic pressure of adults in iodine-sufficient and iodine-excess areas increased and high-density lipoprotein-cholesterol decreased (all P < 0.001). Urinary iodine, thyroid-stimulating hormone, and free thyroxine have a nonlinear correlation with blood glucose (R2 = 0.8174, 0.8264, and 0.8520, respectively). Excessive iodine intake may result in elevated blood glucose and blood pressure and has some influence on blood lipids, and may increase the risk of hypertension and diabetes.

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Citations

Mar 20, 2020·Thyroid : Official Journal of the American Thyroid Association·Mingyue JinZhongyan Shan
Oct 13, 2020·European Journal of Clinical Nutrition·Jie GaoXihua Liu
Jul 12, 2021·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Isabela M BenseñorPaulo A Lotufo
Sep 1, 2021·Biological Trace Element Research·Ji BianJianchao Bian
Dec 3, 2021·Biological Trace Element Research·Li ZhangLixiang Liu

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