Effects of excitation angle strategy on quantitative analysis of hyperpolarized pyruvate

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Christopher M WalkerJames A Bankson

Abstract

Various excitation strategies have been proposed for dynamic imaging of hyperpolarized agents such as [1-13 C]-pyruvate, but the impact of these strategies on quantitative evaluation of signal evolution remains unclear. To better understand their relative performance, we compared the accuracy and repeatability of measurements made using variable excitation angle strategies and conventional constant excitation angle strategies. Signal evolution for constant and variable excitation angle schedules was simulated using a pharmacokinetic model of hyperpolarized pyruvate with 2 chemical pools and 2 physical compartments. Noisy synthetic data were then fit using the same pharmacokinetic model with the apparent chemical exchange term as an unknown, and fit results were compared with simulation parameters to determine accuracy and reproducibility. Constant excitations and a variable excitation strategy that maximizes the HP lactate signal yielded data that supported quantitative analyses with similar accuracy and repeatability. Variable excitation angle strategies that were designed to produce a constant signal level resulted in lower signal and worse quantitative accuracy and repeatability, particularly for longer acquisition times. Th...Continue Reading

References

Aug 22, 2003·Proceedings of the National Academy of Sciences of the United States of America·Klaes GolmanIb Leunbach
Aug 22, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jan H Ardenkjaer-LarsenKlaes Golman
Jul 14, 2006·Proceedings of the National Academy of Sciences of the United States of America·Klaes GolmanMikkel Thaning
Nov 17, 2006·Cancer Research·Klaes GolmanJan Henrik Ardenkjaer-Larsen
Nov 21, 2007·Journal of Magnetic Resonance·Kaz Nagashima
Dec 7, 2007·Proceedings of the National Academy of Sciences of the United States of America·Matthew E MerrittCraig R Malloy
Jul 16, 2008·Journal of Magnetic Resonance·Peder E Z LarsonDaniel B Vigneron
Mar 16, 2011·Neoplasia : an International Journal for Oncology Research·John KurhanewiczCraig R Malloy
Nov 22, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S M KazanG M Tozer
Jul 13, 2013·Journal of Magnetic Resonance·Yan XingPeder E Z Larson
Aug 16, 2013·Science Translational Medicine·Sarah J NelsonJonathan A Murray
Nov 2, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Chang-Yu SunJames A Bankson
Feb 25, 2018·Journal of Magnetic Resonance·Jeremy W GordonPeder E Z Larson
Nov 26, 2018·Neoplasia : an International Journal for Oncology Research·John KurhanewiczRahim Rizi

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Citations

Jan 22, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Rie B OlinJan H Ardenkjaer-Larsen
Feb 11, 2020·Journal of Magnetic Resonance Imaging : JMRI·Jeremy W GordonPeder E Z Larson
Aug 4, 2020·NMR in Biomedicine·Christopher M WalkerJames A Bankson
Apr 7, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Junjie MaJae Mo Park
Jul 3, 2021·Metabolites·Peder Eric Zufall Larson, Jeremy W Gordon
Jul 4, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Philip M LeeDaniel B Vigneron

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