Effects of exenatide on cardiac function, perfusion, and energetics in type 2 diabetic patients with cardiomyopathy: a randomized controlled trial against insulin glargine

Cardiovascular Diabetology
Weena J Y ChenPaul Knaapen

Abstract

Multiple bloodglucose-lowering agents have been linked to cardiovascular events. Preliminary studies showed improvement in left ventricular (LV) function during glucagon-like peptide-1 receptor agonist administration. Underlying mechanisms, however, are unclear. The purpose of this study was to investigate myocardial perfusion and oxidative metabolism in type 2 diabetic (T2DM) patients with LV systolic dysfunction as compared to healthy controls. Furthermore, effects of 26-weeks of exenatide versus insulin glargine administration on cardiac function, perfusion and oxidative metabolism in T2DM patients with LV dysfunction were explored. Twenty-six T2DM patients with LV systolic dysfunction (cardiac magnetic resonance (CMR) derived LV ejection fraction (LVEF) of 47 ± 13%) and 10 controls (LVEF of 59 ± 4%, P < 0.01 as compared to patients) were analyzed. Both myocardial perfusion during adenosine-induced hyperemia (P < 0.01), and coronary flow reserve (P < 0.01), measured by [15O]H2O positron emission tomography (PET), were impaired in T2DM patients as compared to healthy controls. Myocardial oxygen consumption and myocardial efficiency, measured using [11C]acetate PET and CMR derived stroke volume, were not different between the ...Continue Reading

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References

Feb 1, 1986·Journal of the American College of Cardiology·A B NicholsP J Cannon
Feb 1, 1986·Journal of the American College of Cardiology·J S Karliner
Apr 30, 2003·Diabetes Care·Aaron I VinikRoy Freeman
Sep 9, 2004·American Journal of Physiology. Endocrinology and Metabolism·Thomas NyströmAke Sjöholm
Jul 1, 2005·Physiological Reviews·William C StanleyGary D Lopaschuk
Nov 25, 2005·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Inga ThrainsdottirLars Rydén
Sep 5, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Ornella E RimoldiPaolo G Camici
Jul 25, 2007·Circulation·Houman AshrafianLionel H Opie
Apr 18, 2008·Current Cardiology Reports·Helena TuunanenJuhani Knuuti
Sep 5, 2008·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Erick AlexandersonGraciela Alexanderson
Dec 25, 2009·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·P Iozzo
Jan 19, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Mads HalbirkHenrik Wiggers
Jan 29, 2011·European Journal of Nuclear Medicine and Molecular Imaging·Hendrik J HarmsMark Lubberink
Aug 14, 2012·Lancet·Ele Ferrannini, William C Cushman
Sep 25, 2012·Journal of the American College of Cardiology·Catherine N MartiJaved Butler
Sep 3, 2013·The New England Journal of Medicine·Benjamin M SciricaUNKNOWN SAVOR-TIMI 53 Steering Committee and Investigators
Oct 8, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Heinrich TaegtmeyerLouis Hue
Apr 16, 2014·The Lancet. Diabetes & Endocrinology·John J V McMurrayMarc A Pfeffer
Sep 27, 2014·Journal of the American College of Cardiology·Wolfram DoehnerStefan D Anker
Apr 8, 2015·Cardiovascular Diabetology·Keiichi TorimotoYoshiya Tanaka
Sep 18, 2015·The New England Journal of Medicine·Bernard ZinmanUNKNOWN EMPA-REG OUTCOME Investigators

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Citations

May 22, 2020·Circulation Research·Linda R Peterson, Robert J Gropler
Jun 28, 2018·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Hendrik J HarmsJens Sörensen
Dec 7, 2018·Critical Reviews in Food Science and Nutrition·Chao ZhaoHui Cao

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