Effects of exercise dose on endogenous estrogens in postmenopausal women: a randomized trial

Endocrine-related Cancer
Christine M FriedenreichKerry S Courneya

Abstract

Exercise dose comparison trials with biomarker outcomes can identify the amount of exercise required to reduce breast cancer risk and also strengthen the causal inference between physical activity and breast cancer. The Breast Cancer and Exercise Trial in Alberta (BETA) tested whether or not greater changes in estradiol (E2), estrone, and sex hormone-binding globulin (SHBG) concentrations can be achieved in postmenopausal women randomized to 12 months of HIGH (300 min/week) vs MODERATE (150 min/week) volumes of aerobic exercise. BETA included 400 inactive postmenopausal women aged 50-74 years with BMI of 22-40 kg/m(2). Blood was drawn at baseline and 6 and 12 months. Adiposity, physical fitness, diet, and total physical activity were assessed at baseline and 12 months. Intention-to-treat analyses were performed using linear mixed models. At full prescription, women exercised more in the HIGH vs MODERATE group (median min/week (quartiles 1,3): 253 (157 289) vs 137 (111 150); P<0.0001). Twelve-month changes in estrogens and SHBG were <10% on average for both groups. No group differences were found for E2, estrone, SHBG or free E2 changes (treatment effect ratios (95% CI) from linear mixed models: 1.00 (0.96-1.06), 1.02 (0.98-1.05...Continue Reading

Associated Clinical Trials

Sep 15, 2011·Christine Friedenreich

References

Jan 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·M PugeatJ Tourniaire
Apr 18, 2002·Journal of the National Cancer Institute·T KeyUNKNOWN Endogenous Hormones and Breast Cancer Collaborative Group
Mar 14, 2003·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Arturo FigueroaTimothy G Lohman
Sep 26, 2003·Scandinavian Journal of Medicine & Science in Sports·T-M AsikainenI Vuori
Feb 10, 2004·Medicine and Science in Sports and Exercise·Gina M MorssSteven N Blair
Jul 31, 2004·Maturitas·Jennifer L Copeland, Mark S Tremblay
Aug 17, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Andrew G RundleHabibul Ahsan
Mar 10, 2006·American Journal of Epidemiology·Christine M FriedenreichRachel Ballard-Barbash
May 24, 2008·Maturitas·Fabio L OrsattiRoberto C Burini
Nov 7, 2008·International Journal of Cancer. Journal International Du Cancer·Reiko SuzukiAlicja Wolk
Mar 5, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Robert L GrubbUNKNOWN PLCO Project Team
Aug 19, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Evelyn M MonninkhofAlbertine J Schuit
Feb 18, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christine M FriedenreichKerry S Courneya
Jun 10, 2011·American Journal of Physiology. Endocrinology and Metabolism·Pernille HojmanBente Klarlund Pedersen
Jun 18, 2011·Medicine and Science in Sports and Exercise·Barbara E AinsworthArthur S Leon
Jul 21, 2011·British Journal of Cancer·UNKNOWN Endogenous Hormones and Breast Cancer Collaborative GroupH D Strickler
Jan 13, 2012·CA: a Cancer Journal for Clinicians·Lawrence H KushiUNKNOWN American Cancer Society 2010 Nutrition and Physical Activity Guidelines Advisory Committee
Jan 14, 2012·Obesity·Stefanie LiedtkeKaren Steindorf
May 2, 2012·Menopause : the Journal of the North American Menopause Society·Damon L SwiftTimothy S Church
May 23, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kristin L CampbellAnne McTiernan
Jan 1, 2013·Breast Cancer Research and Treatment·Yili WuShan Kang
Jan 4, 2013·Breast Cancer Research and Treatment·Xuehong ZhangSusan E Hankinson
May 15, 2013·The Journal of Clinical Endocrinology and Metabolism·Michael E JonesAnthony J Swerdlow
Jun 20, 2013·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Theresa A HastertEmily White
Oct 1, 2013·The Breast : Official Journal of the European Society of Mastology·Elizabeth Folkerd, Mitch Dowsett
Feb 25, 2014·Current Nutrition Reports·Heather K NeilsonChristine M Friedenreich
Aug 20, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Shelley S TworogerSusan E Hankinson
Dec 7, 2014·BMC Cancer·Christine M FriedenreichKerry S Courneya

❮ Previous
Next ❯

Citations

Mar 23, 2018·The International Journal of Behavioral Nutrition and Physical Activity·Jessica McNeilChristine M Friedenreich
Aug 17, 2018·BioMed Research International·Jordana C M Godinho-MotaRuffo Freitas-Junior
Jul 19, 2018·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Chelsea R StoneKerry S Courneya
Aug 31, 2018·Nature Reviews. Gastroenterology & Hepatology·Cornelia M UlrichStephen D Hursting
Apr 9, 2020·European Journal of Applied Physiology·Paola Gonzalo-EncaboAlberto Pérez-López
Nov 5, 2016·Nutrition and Metabolic Insights·Salma A AbdelmagidDavid W L Ma
Sep 20, 2019·Future Science OA·Mohamad Aljofan, Dieter Riethmacher
Aug 7, 2019·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Christine M FriedenreichKerry S Courneya
Mar 20, 2021·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Paola Gonzalo-EncaboChristine M Friedenreich

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.